Title:
APPLICATION OF CYCLIC GMP-AMP (CGAMP) IN COMBINATION WITH BEVACIZUMAB IN TUMOR RESISTANCE
Document Type and Number:
WIPO Patent Application WO/2017/045595
Kind Code:
A1
Abstract:
Application of cyclic GMP-AMP (cGAMP) in combination with bevacizumab in tumor resistance. A research shows that combination of cGAMP and bevacizumab can significantly inhibit growth of multiple tumor cells, has an obvious tumor resistance effect, and can be used for preparing antitumor drugs. A model of subcutaneously transplantable tumors in a C57BL/6 mouse shows that the combination of the cGAMP and the bevacizumab has significant inhibition effects on an adenocarcinoma cell line MC38, a lung cancer cell line LLC, melanoma cell lines B16-F10, and a colon cancer cell MC38, and the effects are better than a single medication effect. Therefore, the combination of the cGAMP and the bevacizumab can be used for treating tumors.
Inventors:
ZHANG YUERU (CN)
YUAN HONG (CN)
TAN YING XUAN (CN)
TAN XIANGSHI (CN)
YUAN HONG (CN)
TAN YING XUAN (CN)
TAN XIANGSHI (CN)
Application Number:
PCT/CN2016/098931
Publication Date:
March 23, 2017
Filing Date:
September 13, 2016
Export Citation:
Assignee:
LIAOCHENG CITY ORIENT BIOMEDICAL TECH CO LTD (CN)
International Classes:
A61K31/7084; A61P35/00; C07K16/00; C12P21/08
Domestic Patent References:
| WO2014179760A1 | 2014-11-06 | |||
| WO2014189805A1 | 2014-11-27 | |||
| WO2014099824A1 | 2014-06-26 |
Foreign References:
| CN103908468A | 2014-07-09 |
Other References:
LI, WENKAI: "kang4zhong3liu2xue2guan2 shenglcheng2zhi4liao2 de xin1ce4lue4", JOURNAL OF BINZHOU MEDICAL UNIVERSITY, vol. 37, no. 5, 31 October 2014 (2014-10-31), pages 379 - 381
QANG, PENG, DANLKANG4 AVASTIN(BEVACIZUMAB) ZAI4 ZHONG3LIU2 ZHI4LIAO2 ZHONGLDE YING4TONG4 YAN2JIUL JIN4ZHAN3, GUO2WAI4 YILXUE2 ZHONTG3LIU2 FENLCE4, vol. 31, 31 December 2004 (2004-12-31), pages 1 - 4
QANG, PENG, DANLKANG4 AVASTIN(BEVACIZUMAB) ZAI4 ZHONG3LIU2 ZHI4LIAO2 ZHONGLDE YING4TONG4 YAN2JIUL JIN4ZHAN3, GUO2WAI4 YILXUE2 ZHONTG3LIU2 FENLCE4, vol. 31, 31 December 2004 (2004-12-31), pages 1 - 4
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