Title:
APPLICATION OF CYCLIC NONPOLAR DIPEPTIDE FOR PREPARING ANTIHYPERTENSIVE DRUG OR HEALTH CARE PRODUCT
Document Type and Number:
WIPO Patent Application WO/2019/006952
Kind Code:
A1
Abstract:
The invention relates to the application of a cyclic nonpolar dipeptide for preparing an antihypertensive drug or a health care product. Virtual screening has been performed on a dipeptide based on ACE inhibitory effects according to a previously detected ACE enzyme crystal structure by using a software and implementing a docking method, and experiments have been conducted to verify the ACE inhibitory activity of the virtually screened dipeptide. It has been discovered that the nonpolar cyclic amino acid dipeptide with the N terminal optimizes the ACE inhibitory activity.
Inventors:
PAN WUGUANG (CN)
ZHU WEI (CN)
ZHU WEI (CN)
Application Number:
PCT/CN2017/111644
Publication Date:
January 10, 2019
Filing Date:
November 17, 2017
Export Citation:
Assignee:
WITHYOU BIOTECHNOLOGY CO LTD (CN)
International Classes:
A61K38/05; A61P9/12; C07K5/06; C07K5/065
Domestic Patent References:
| WO2016023150A1 | 2016-02-18 |
Foreign References:
| EP2161029A1 | 2010-03-10 | |||
| EP2161028A1 | 2010-03-10 |
Other References:
LUNOW, DIANA ET AL.: "Selective release of ACE-inhibiting tryptophan-containing dipeptides from food proteins by enzymatic hydrolysis", EUR FOOD RES TECHNOL, 28 May 2013 (2013-05-28), XP035311087
Attorney, Agent or Firm:
JIAQUAN IP LAW FIRM (CN)
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