Title:
APPLICATION OF METFORMIN IN THE PREPARATION OF DRUGS FOR PREVENTION AND TREATMENT OF OSTEOARTHRITIS AND FOR ALLEVIATION OF PAIN SYMPTOMS CAUSED BY OSTEOARTHRITIS
Document Type and Number:
WIPO Patent Application WO/2019/029526
Kind Code:
A1
Abstract:
Disclosed in the present invention are applications of metformin in the preparation of drugs for the prevention and treatment of osteoarthritis and for the alleviation of pain symptoms caused by osteoarthritis. The invention has a definite curative effect on OA, and opens up a new application for the traditional hypoglycaemic drug metformin. Metformin is safe, has no obvious hypoglycaemic effect on healthy people, does not cause hypoglycaemia, and is low cost, highly tolerated, and easily accepted by patients.
Inventors:
LEI GUANGHUA (CN)
ZENG CHAO (CN)
WEI JIE (CN)
CUI YANG (CN)
DING XIANG (CN)
LI HUI (CN)
ZENG CHAO (CN)
WEI JIE (CN)
CUI YANG (CN)
DING XIANG (CN)
LI HUI (CN)
Application Number:
PCT/CN2018/099180
Publication Date:
February 14, 2019
Filing Date:
August 07, 2018
Export Citation:
Assignee:
XIANGYA HOSPITAL CENTRAL SOUTH UNIV (CN)
International Classes:
A61K31/155; A61P19/02; A61P19/08; A61P29/00
Other References:
TAN, QUIINGMEI ET AL.: "Metformin Protects Osteoarthritis in Mice by Regulating the AMPK Signaling Pathways", CHINESE JOURNAL OF CLINICAL ANATOMY, vol. 35, no. 4, 25-07-2017, pages 413 - 414
Attorney, Agent or Firm:
CHANGSHA ZONEKEY PATENT LAW FIRM et al. (CN)
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