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Title:
APPLICATION OF NONPOLAR DIPEPTIDE FOR PREPARING ANTIHYPERTENSIVE DRUG OR HEALTH CARE PRODUCT
Document Type and Number:
WIPO Patent Application WO/2019/006951
Kind Code:
A1
Abstract:
The invention relates to an application of a dipeptide for preparing antihypertensive drug or health care product. Virtual screening has been performed on a dipeptide based on ACE inhibitory effects according to a previously detected ACE enzyme crystal structure by using a self-developed software and implementing a docking method, and experiments have been conducted to verify the ACE inhibitory activity of the virtually screened dipeptide. It has been discovered that the nonpolar acyclic amino acid dipeptide optimizes ACE inhibitory activity.

Inventors:
PAN, Wuguang (Room G104, G District of International Business IncubatorNo. 3, Lanyue Road, Science City,Hi-Tech Industrial Development Zon, Guangzhou Guangdong 0, 510630, CN)
ZHU, Wei (Room G104, G District of International Business IncubatorNo. 3, Lanyue Road, Science City,Hi-Tech Industrial Development Zon, Guangzhou Guangdong 0, 510630, CN)
Application Number:
CN2017/111643
Publication Date:
January 10, 2019
Filing Date:
November 17, 2017
Export Citation:
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Assignee:
WITHYOU BIOTECHNOLOGY CO., LTD. (Room G104, G District of International Business IncubatorNo. 3, Lanyue Road, Science City,Hi-Tech Industrial Development Zon, Guangzhou Guangdong 0, 510630, CN)
International Classes:
A61K38/05; A61P9/12; C07K5/06; C07K5/062
Foreign References:
CN105111279A2015-12-02
CN105330721A2016-02-17
EP2161029A12010-03-10
CN102432670A2012-05-02
Other References:
ENARI, H. ET AL.: "Identification of Angiotensin I-Converting Enzyme Inhibitory Peptides Derived from Salmon Muscle and Their Antihypertensive Effect", FISHERIES SCIENCE, vol. 74, no. 4, 3 August 2008 (2008-08-03), XP009156360
Attorney, Agent or Firm:
JIAQUAN IP LAW FIRM (ZHANG, PingNo. 910, Building A, Winner Plaza,No. 100, West Huangpu Avenue, Tianhe Distric, Guangzhou Guangdong 7, 510627, CN)
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