Title:
APPLICATION OF OXYBERBERINE IN PREPARATION OF DRUGS FOR METABOLIC DISEASES, AND PHARMACEUTICAL COMPOSITION COMPRISING OXYBERBERINE
Document Type and Number:
WIPO Patent Application WO/2022/062518
Kind Code:
A1
Abstract:
The present invention relates to the technical field of biomedicines. Disclosed are an application of oxyberberine in preparation of drugs for metabolic diseases, and a pharmaceutical composition comprising the oxyberberine. The oxyberberine can be used for preparing the drugs for the metabolic diseases, and can also be used for preparing the pharmaceutical composition having the functions of reducing blood sugar, reducing blood fat, and reducing uric acid. The oxyberberine has good functions of reducing blood sugar, reducing blood fat, and reducing uric acid in models of diabetes, fatty liver and hyperuricemia, has certain indexes with function intensity superior to or close to that of positive drugs and berberine, has small toxic and side effects, and can improve pathological injuries of related organs. The oxyberberine is expected to be developed into a class of innovative drugs having the functions of reducing blood sugar, reducing blood fat, and reducing uric acid, and is used for clinically treating the metabolic diseases such as obesity, diabetes, fatty liver, and gout.
Inventors:
SU ZIREN (CN)
CHEN JIANNAN (CN)
LI YUCUI (CN)
XIE JIANHUI (CN)
LIU YUHONG (CN)
XIE YOULIANG (CN)
HUANG XIAOQI (CN)
CHEN JIANNAN (CN)
LI YUCUI (CN)
XIE JIANHUI (CN)
LIU YUHONG (CN)
XIE YOULIANG (CN)
HUANG XIAOQI (CN)
Application Number:
PCT/CN2021/102587
Publication Date:
March 31, 2022
Filing Date:
June 27, 2021
Export Citation:
Assignee:
GUANGZHOU UNIV OF CHINESE MEDICINE GUANGZHOU INSTITUTE OF CHINESE MEDICINE (CN)
International Classes:
A61P1/16; A61K31/4375; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P13/12; A61P19/06
Domestic Patent References:
| WO2010104595A1 | 2010-09-16 |
Foreign References:
| CN112138007A | 2020-12-29 | |||
| US20060223838A1 | 2006-10-05 |
Other References:
HONG-YING CHEN; XIAO-LI YE; XUE-LONG CUI; KAI HE; YA-NAN JIN; ZHU CHEN; XUE-GANG LI;: "Cytotoxicity and antihyperglycemic effect of minor constituents fromin HepG2 cells", FITOTERAPIA, IDB HOLDING, MILAN., IT, vol. 83, no. 1, 13 September 2011 (2011-09-13), IT , pages 67 - 73, XP028391883, ISSN: 0367-326X, DOI: 10.1016/j.fitote.2011.09.014
WANG, YONGLING: "Application of High-Speed Countercurrent Chromatography to the Rapid Screening of Bioactive Components from Chinese Materia Medica (CMM) and Natural Products", SHI JIE KE XUE JI SHU ZA ZHI, CN, vol. 19, no. 2, 1 January 2017 (2017-01-01), CN , pages 265 - 275, XP055914535, ISSN: 1674-3849, DOI: 10.11842/wst.2017.02.013
LI CAILAN, AI GAOXIANG, WANG YONGFU, LU QIANG, LUO CHAODAN, TAN LIHUA, LIN GUOSHENG, LIU YUHONG, LI YUCUI, ZENG HUIFANG, CHEN JIAN: "Oxyberberine, a novel gut microbiota-mediated metabolite of berberine, possesses superior anti-colitis effect: Impact on intestinal epithelial barrier, gut microbiota profile and TLR4-MyD88-NF-κB pathway", PHARMACOLOGICAL RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 152, 1 February 2020 (2020-02-01), AMSTERDAM, NL, pages 104603, XP055914508, ISSN: 1043-6618, DOI: 10.1016/j.phrs.2019.104603
RU LIU-BRYAN, PETER SCOTT, ANYA SYDLASKE, DAVID M. ROSE, AND ROBERT TERKELTAUB: "Innate Immunity Conferred by Toll-like Receptors 2 and 4 and Myeloid Differentiation Factor 88 Expression is Pivotal to Monosodium Urate Monohydrate Crystal– induced Inflammation", ARTHRITIS & RHEUMATISM, vol. 52, no. 9, 1 September 2005 (2005-09-01), pages 2936 - 2946, XP055914519, DOI: 10.1002/art.21238
JIALAL ISHWARLAL, KAUR HARMEET, DEVARAJ SRIDEVI: "Toll-like Receptor Status in Obesity and Metabolic Syndrome: A Translational Perspective", JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, THE ENDOCRINE SOCIETY, US, vol. 99, no. 1, 1 January 2014 (2014-01-01), US , pages 39 - 48, XP055914527, ISSN: 0021-972X, DOI: 10.1210/jc.2013-3092
WANG, YONGLING: "Application of High-Speed Countercurrent Chromatography to the Rapid Screening of Bioactive Components from Chinese Materia Medica (CMM) and Natural Products", SHI JIE KE XUE JI SHU ZA ZHI, CN, vol. 19, no. 2, 1 January 2017 (2017-01-01), CN , pages 265 - 275, XP055914535, ISSN: 1674-3849, DOI: 10.11842/wst.2017.02.013
LI CAILAN, AI GAOXIANG, WANG YONGFU, LU QIANG, LUO CHAODAN, TAN LIHUA, LIN GUOSHENG, LIU YUHONG, LI YUCUI, ZENG HUIFANG, CHEN JIAN: "Oxyberberine, a novel gut microbiota-mediated metabolite of berberine, possesses superior anti-colitis effect: Impact on intestinal epithelial barrier, gut microbiota profile and TLR4-MyD88-NF-κB pathway", PHARMACOLOGICAL RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 152, 1 February 2020 (2020-02-01), AMSTERDAM, NL, pages 104603, XP055914508, ISSN: 1043-6618, DOI: 10.1016/j.phrs.2019.104603
RU LIU-BRYAN, PETER SCOTT, ANYA SYDLASKE, DAVID M. ROSE, AND ROBERT TERKELTAUB: "Innate Immunity Conferred by Toll-like Receptors 2 and 4 and Myeloid Differentiation Factor 88 Expression is Pivotal to Monosodium Urate Monohydrate Crystal– induced Inflammation", ARTHRITIS & RHEUMATISM, vol. 52, no. 9, 1 September 2005 (2005-09-01), pages 2936 - 2946, XP055914519, DOI: 10.1002/art.21238
JIALAL ISHWARLAL, KAUR HARMEET, DEVARAJ SRIDEVI: "Toll-like Receptor Status in Obesity and Metabolic Syndrome: A Translational Perspective", JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, THE ENDOCRINE SOCIETY, US, vol. 99, no. 1, 1 January 2014 (2014-01-01), US , pages 39 - 48, XP055914527, ISSN: 0021-972X, DOI: 10.1210/jc.2013-3092
Attorney, Agent or Firm:
GUANGZHOU HUAXUE INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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