APPLICATION OF PEPTIDYLARGININE DEIMINASE 1 IN PREPARATION OF REAGENT FOR CLINICAL DIAGNOSIS OF TUMORS - SHANDONG CHUANGXIN PHARMACEUTICAL RES AND DEV CO LTD

Title:

APPLICATION OF PEPTIDYLARGININE DEIMINASE 1 IN PREPARATION OF REAGENT FOR CLINICAL DIAGNOSIS OF TUMORS

Document Type and Number:

WIPO Patent Application WO/2016/082444

Kind Code:

A1

Abstract:

An application of peptidylarginine deiminase 1 in preparation of a reagent or detection object for clinical diagnosis of tumors, wherein the tumors comprise uterine cancers, liver cancers, gastric cancers, esophageal cancers, ovarian cancers and lung cancers. In the specific application, an antibody against peptidylarginine deiminase 1 is prepared by a conventional method, and a qualitative or quantitative method and a matching kit for detecting peptidylarginine deiminase 1 are established. A blood diagnosis reagent for diagnosing tumors comprises a peptidylarginine deiminase 1 antibody, an HRP-IgG antibody and conventional reagents in the blood diagnosis reagent, wherein the conventional reagents in the blood diagnosis reagent comprise a carbonate buffer solution, a PBST lotion, a blocking solution, a developing solution and a stop solution. Experiments prove that PAD1 can be applied as a tumor blood marker, and PAD1 has feasibility as the tumor marker.

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Inventors:

CHANG XIAOTIAN (CN)
XING YANQIU (CN)
MA FANG (CN)
YANG DONGXIA (CN)

Application Number:

PCT/CN2015/077352

Publication Date:

June 02, 2016

Filing Date:

April 24, 2015

Export Citation:

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Assignee:

SHANDONG CHUANGXIN PHARMACEUTICAL RES AND DEV CO LTD (CN)

International Classes:

G01N33/573

Domestic Patent References:

WO2010060103A1	2010-05-27
WO2003030725A2	2003-04-17

Foreign References:

EP2311986A1	2011-04-20
JP2006053113A	2006-02-23
CN104360062A	2015-02-18

Other References:

CHEN, CHU ET AL.: "Gene Expression Profiling Identifies Genes Predictive of Oral Squamous Cell Carcinoma", CANCER EPIDEMIOL BIOMARKERS PREV., vol. 17, no. 8, 31 August 2008 (2008-08-31), pages 1 - 18
ABDEEN, S.M. ET AL.: "Peptidyl Arginine Deiminase: a Novel Immunohistochemical Marker for Liver Fibrosis in Patients with Chronic Hepatitis", ACTA HISTOCHEMICA, vol. 112, no. 6, 30 November 2010 (2010-11-30), pages 592 - 603

Attorney, Agent or Firm:

JINAN LUKE PATENT AGENT CO., LTD. (CN)
济南鲁科专利代理有限公司 (CN)

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