Title:
APPLICATION OF POLYPHENOL COMPOUND
Document Type and Number:
WIPO Patent Application WO/2022/183493
Kind Code:
A1
Abstract:
Disclosed is the application of a polyphenol compound, in particular the application thereof in the preparation of drugs for the prevention and treatment of cerebral ischaemia. The polyphenol compound particularly relates to proanthocyanidin B 3. In vitro experiments show that the polyphenol compound proanthocyanidin B3 can inhibit the pyroptosis and apoptosis response and cellular inflammation of HT22 hippocampal neurons treated with OGD/R; in vivo experiments show that the compound can reduce the apoptosis, apoptotic response, and cellular inflammation caused by cerebral ischaemia, and can reduce the area of infarction caused by cerebral ischaemia, improve neurological function scores, and improve cerebral blood flow.
Inventors:
CHANG JUN (CN)
LIU XINHUA (CN)
DING CHEN (CN)
WANG JINGHUAN (CN)
JIN LIN (CN)
WANG HAIKUN (CN)
LIU XINHUA (CN)
DING CHEN (CN)
WANG JINGHUAN (CN)
JIN LIN (CN)
WANG HAIKUN (CN)
Application Number:
PCT/CN2021/079344
Publication Date:
September 09, 2022
Filing Date:
March 05, 2021
Export Citation:
Assignee:
UNIV FUDAN (CN)
International Classes:
A61K31/353; A61P9/00
Foreign References:
| CN102688230A | 2012-09-26 | |||
| CN101530410A | 2009-09-16 |
Other References:
GUO ZHI, XU LI: " Proanthocyanidins: Plant Drugs Having Broad Development Prospects", WORLD PHYTOMEDICINES, CN, vol. 11, no. 5, 31 December 1996 (1996-12-31), CN , pages 196 - 2045, XP055963845, ISSN: 1001-6856
WU SHUANGCHAN, YUAN YUE, JIAN LI, ZHIKE LI, XIAOFEI LI, YUNHUI NIU, JIN XIANG, HONG DING : "Procyanidin B2 attenuates neurological deficits and blood–brain barrier disruption in a rat model of cerebral ischemia", MOLECULAR NUTRITION & FOOD RESEARCH, WILEY - VCH VERLAG, WEINHEIM, DE, vol. 59, no. 10, 26 August 2015 (2015-08-26), DE , pages 1930 - 1941, XP055963847, ISSN: 1613-4125, DOI: 10.1002/mnfr.201500181
FENG LI, HAI XIE, YING GAO, TONGXIA ZHAN: "Dose-dependent effects of procyanidin on nerve growth factor expression following cerebral ischemia/reperfusion injury in rats", NEURAL REGENERATION RESEARCH, MEDKNOW PUBLICATIONS AND MEDIA PVT. LTD., CN, vol. 3, no. 4, 30 April 2008 (2008-04-30), CN , pages 390 - 393, XP009539361, ISSN: 1673-5374
YANG, BO ET AL.: "Procyanidins exhibits neuroprotective activities against cerebral ischemia reperfusion injury by inhibiting TLR4-NLRP3 inflammasome signal pathway", PSYCHOPHARMACOLOGY, vol. 237, no. 11, 30 November 2020 (2020-11-30), XP037270077, ISSN: 0033-3158, DOI: 10.1007/s00213-020-05610-z
WU SHUANGCHAN, YUAN YUE, JIAN LI, ZHIKE LI, XIAOFEI LI, YUNHUI NIU, JIN XIANG, HONG DING : "Procyanidin B2 attenuates neurological deficits and blood–brain barrier disruption in a rat model of cerebral ischemia", MOLECULAR NUTRITION & FOOD RESEARCH, WILEY - VCH VERLAG, WEINHEIM, DE, vol. 59, no. 10, 26 August 2015 (2015-08-26), DE , pages 1930 - 1941, XP055963847, ISSN: 1613-4125, DOI: 10.1002/mnfr.201500181
FENG LI, HAI XIE, YING GAO, TONGXIA ZHAN: "Dose-dependent effects of procyanidin on nerve growth factor expression following cerebral ischemia/reperfusion injury in rats", NEURAL REGENERATION RESEARCH, MEDKNOW PUBLICATIONS AND MEDIA PVT. LTD., CN, vol. 3, no. 4, 30 April 2008 (2008-04-30), CN , pages 390 - 393, XP009539361, ISSN: 1673-5374
YANG, BO ET AL.: "Procyanidins exhibits neuroprotective activities against cerebral ischemia reperfusion injury by inhibiting TLR4-NLRP3 inflammasome signal pathway", PSYCHOPHARMACOLOGY, vol. 237, no. 11, 30 November 2020 (2020-11-30), XP037270077, ISSN: 0033-3158, DOI: 10.1007/s00213-020-05610-z
Attorney, Agent or Firm:
SHANGHAI BESINGIP INTELLECTUAL PROPERTY AGENCY CO., LTD (CN)
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