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Patent Searching and Data


Title:
APPLICATION OF PROTEIN IN PREPARING DRUG FOR PREVENTING OR TREATING COMPLICATION OF DIABETES
Document Type and Number:
WIPO Patent Application WO/2019/179338
Kind Code:
A1
Abstract:
Disclosed is an application of secretory DSS1 protein in preparing a drug for preventing or treating a complication of diabetes. The secretory DSS1 can bind to advanced glycation end products and block cytotoxicity induced thereby, thereby relieving a symptom in an animal model having a complication of diabetes.

Inventors:
ZHANG YINGHAO (CN)
YAN GUIRUI (CN)
FU JINGPENG (CN)
Application Number:
PCT/CN2019/077857
Publication Date:
September 26, 2019
Filing Date:
March 12, 2019
Export Citation:
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Assignee:
SHANGHAI CLEAR FLUID BIOMEDICAL SCIENCE & TECH CO LTD (CN)
International Classes:
A61K38/17; A61P9/00; A61P9/10; A61P13/12
Foreign References:
CN107573412A2018-01-12
Other References:
KRAGELUND, BB.: "DSS1/Sem1, a Multifunctional and Intrinsically Disordered Protein", TRENDS IN BIOCHEMICAL SCIENCES, vol. 41, no. 5, 31 May 2016 (2016-05-31), pages 446 - 459, XP029523207
KRISTENSEN, CN: "Depletion of DSS1 protein disables homologous recombinational repair in human cells", MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, vol. 694, 10 December 2010 (2010-12-10), pages 60 - 64, XP027516240
Attorney, Agent or Firm:
BEIJING UTC LIANFENG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
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