Title:
APPLICATION OF RUBIACEAE TYPE CYCLIC PEPTIDE COMPOUNDS IN PREPARATION OF DRUGS AS CGAS-STING SIGNAL PATHWAY ACTIVATORS
Document Type and Number:
WIPO Patent Application WO/2021/218965
Kind Code:
A1
Abstract:
Disclosed in the present invention are application of a class of Rubiaceae type cyclic peptide compounds or pharmaceutically acceptable salts thereof in preparation of drugs as cGAS-STING signal pathway activators. and application of the Rubiaceae type cyclic peptide compounds or pharmaceutically acceptable salts thereof as cGAS-STING signal pathway activators in the preparation of drugs for the treatment and prevention of related cancers.
Inventors:
TAN NINGHUA (CN)
WANG CHEN (CN)
WANG ZHE (CN)
WANG JIA (CN)
WANG CHEN (CN)
WANG ZHE (CN)
WANG JIA (CN)
Application Number:
PCT/CN2021/090253
Publication Date:
November 04, 2021
Filing Date:
April 27, 2021
Export Citation:
Assignee:
UNIV CHINA PHARMA (CN)
International Classes:
A61K38/12; A61P35/00; A61P35/02
Foreign References:
| CN107496901A | 2017-12-22 | |||
| CN103880929A | 2014-06-25 | |||
| CN103877562A | 2014-06-25 | |||
| CN104829696A | 2015-08-12 | |||
| CN107970432A | 2018-05-01 | |||
| CN104193808A | 2014-12-10 | |||
| CN111420025A | 2020-07-17 |
Other References:
CHEN JUANJUAN, ZHANG PINGAN: "Advances in cGAS-STING Signaling Pathway in Cancer", AIZHENG JINZHAN = ONCOLOGY PROGRESS, ZHONGGUO XIEHE YIKE DAXUE CHUBANSHE, CN, vol. 17, no. 4, 25 February 2019 (2019-02-25), CN , XP055861052, ISSN: 1672-1535, DOI: 10.11877/j.issn.1672-1535.2019.17.04.03
ZHE WANG, SIMENG ZHAO, LIHUA SONG, YUZHI PU, QIANG WANG, GUANGZHI ZENG, XING LIU, MING BAI, SHAO LI, FABAO GAO, LIJUAN CHEN, CHEN : "Natural cyclopeptide RA-V inhibits the NF-κB signaling pathway by targeting TAK1", CELL DEATH & DISEASE, vol. 9, no. 7, 1 July 2018 (2018-07-01), XP055718053, DOI: 10.1038/s41419-018-0743-2
FAN, J.T. ; CHEN, Y.S. ; XU, W.Y. ; DU, L. ; ZENG, G.Z. ; ZHANG, Y.M. ; SU, J. ; LI, Y. ; TAN, N.H.: "Rubiyunnanins A and B, two novel cyclic hexapeptides from Rubia yunnanensis", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM , NL, vol. 51, no. 52, 29 December 2010 (2010-12-29), Amsterdam , NL , pages 6810 - 6813, XP027516784, ISSN: 0040-4039, DOI: 10.1016/j.tetlet.2010.07.066
FAN, J.T. ; SU, J. ; PENG, Y.M. ; LI, Y. ; LI, J. ; ZHOU, Y.B. ; ZENG, G.Z. ; YAN, H. ; TAN, N.H.: "Rubiyunnanins C-H, cytotoxic cyclic hexapeptides from Rubia yunnanensis inhibiting nitric oxide production and NF-@kB activation", BIOORGANIC, ELSEVIER, AMSTERDAM, NL, vol. 18, no. 23, 1 December 2010 (2010-12-01), AMSTERDAM, NL, pages 8226 - 8234, XP027546679, ISSN: 0968-0896
ZHE WANG, SIMENG ZHAO, LIHUA SONG, YUZHI PU, QIANG WANG, GUANGZHI ZENG, XING LIU, MING BAI, SHAO LI, FABAO GAO, LIJUAN CHEN, CHEN : "Natural cyclopeptide RA-V inhibits the NF-κB signaling pathway by targeting TAK1", CELL DEATH & DISEASE, vol. 9, no. 7, 1 July 2018 (2018-07-01), XP055718053, DOI: 10.1038/s41419-018-0743-2
FAN, J.T. ; CHEN, Y.S. ; XU, W.Y. ; DU, L. ; ZENG, G.Z. ; ZHANG, Y.M. ; SU, J. ; LI, Y. ; TAN, N.H.: "Rubiyunnanins A and B, two novel cyclic hexapeptides from Rubia yunnanensis", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM , NL, vol. 51, no. 52, 29 December 2010 (2010-12-29), Amsterdam , NL , pages 6810 - 6813, XP027516784, ISSN: 0040-4039, DOI: 10.1016/j.tetlet.2010.07.066
FAN, J.T. ; SU, J. ; PENG, Y.M. ; LI, Y. ; LI, J. ; ZHOU, Y.B. ; ZENG, G.Z. ; YAN, H. ; TAN, N.H.: "Rubiyunnanins C-H, cytotoxic cyclic hexapeptides from Rubia yunnanensis inhibiting nitric oxide production and NF-@kB activation", BIOORGANIC, ELSEVIER, AMSTERDAM, NL, vol. 18, no. 23, 1 December 2010 (2010-12-01), AMSTERDAM, NL, pages 8226 - 8234, XP027546679, ISSN: 0968-0896
Attorney, Agent or Firm:
NANJING SUGAO PATENT AND TRADEMARK FIRM ( ORDINARY PARTNERSHIP ) (CN)
Download PDF: