Title:
APPLICATION OF ZIKV ATTENUATED STRAIN IN TREATMENT OF BRAIN GLIOMA
Document Type and Number:
WIPO Patent Application WO/2019/144874
Kind Code:
A1
Abstract:
The present invention relates to the tumor treatment field, and discloses an application of ZIKV attenuated strain in treatment of brain glioma. According to the present invention, the use of ZIKV attenuated strain can effectively treat brain glioma and inhibit its development.
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Inventors:
QIN CHENGFENG (CN)
MAN JIANGHONG (CN)
SHI PEI-YONG (US)
CHEN QI (CN)
WU JIN (CN)
MAN JIANGHONG (CN)
SHI PEI-YONG (US)
CHEN QI (CN)
WU JIN (CN)
Application Number:
PCT/CN2019/072763
Publication Date:
August 01, 2019
Filing Date:
January 23, 2019
Export Citation:
Assignee:
ACAD OF MILITARY MEDICAL SCIENCES (CN)
SHI PEI YONG (US)
SHI PEI YONG (US)
International Classes:
A61K35/76; A61P35/00
Other References:
CHEN, QI ET AL.: "Treatment of Human Glioblastoma with A Live Attenuated Zika Virus Vaccine Candidate", HOST-MICROBE BIOLOGY, vol. 9, no. 5, 18 September 2018 (2018-09-18), pages 1 - 13, XP055627648
SHAN, CHAO ET AL.: "A Live-attenuated Zika Virus Vaccine Candidate Induces Sterilizing Immunity in Mouse Models", NATURE MEDICINE, vol. 23, no. 6, 10 April 2017 (2017-04-10), pages 763 - 767, XP055539486, doi:10.1038/nm.4322
Z HU, ZHE ET AL.: "Zika Virus has Oncolytic Activity Against Glioblastoma Stem Cells", J. EXP. MED, vol. 214, no. 10, 5 September 2017 (2017-09-05), pages 2843 - 2857, XP055436428, doi:10.1084/jem.20171093
SHAN, CHAO ET AL.: "A Live-attenuated Zika Virus Vaccine Candidate Induces Sterilizing Immunity in Mouse Models", NATURE MEDICINE, vol. 23, no. 6, 10 April 2017 (2017-04-10), pages 763 - 767, XP055539486, doi:10.1038/nm.4322
Z HU, ZHE ET AL.: "Zika Virus has Oncolytic Activity Against Glioblastoma Stem Cells", J. EXP. MED, vol. 214, no. 10, 5 September 2017 (2017-09-05), pages 2843 - 2857, XP055436428, doi:10.1084/jem.20171093
Attorney, Agent or Firm:
RUNPING & PARTNERS (CN)
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