APPLICATIONS OF AND EVALUATION METHOD FOR L-TYPE VOLTAGE-GATED CALCIUM CHANNEL, AND DRUGS

WIPO Patent Application WO/2019/091433

A1

The present invention provides applications of an L-type voltage-gated calcium channel agonist in the preparation of drugs for treating uresis dysfunctions of bladders of mammals, and a method for evaluating the L-type voltage-gated calcium channel agonist in regulation of uresis dysfunctions of the bladders of the mammals.

YU WEIQUN (CN)

PCT/CN2018/114637

May 16, 2019

November 08, 2018

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YU WEIQUN (CN)

A61K31/4422; A61K31/40; A61P13/00; A61P13/10

WO2008157205A2

2008-12-24

DIEDERICHS, W. ET AL.: "COMPARISON OF BAY K-8644, NITRENDIPINE AND ATROPINE ON SPONTANEOUS AND PELVIC-NERVE-INDUCED BLADDER CONTRACTIONS ON RAT BLADDER IN VIVO", UROLOGICAL RESEARCH, vol. 20, no. 1, 31 December 1992 (1992-12-31), pages 49 - 53
HERTLE, L . ET AL.: "Stimulation of voltage-dependent contractions by calcium channel activator BAY K 8644 in the human upper urinary tract in vitro", J UROL ., vol. 141, no. 4, 30 April 1989 (1989-04-30), pages 1014 - 1018
MERAV, M. ET AL.: "Conformational Changes Induced in Voltage-gated Calcium Channel Cavl.2 by BayK 8644 or FPL64176 Modify the Kinetics of Secretion Independently of Ca2+ Influx", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 285, no. 10, 5 March 2010 (2010-03-05), pages 6996 - 7005, XP055607588

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