Title:
APPLICATIONS OF IMINOSTILBENE IN TERMS OF PREVENTING AND TREATING CARDIAC CEREBRAL ISCHEMIA/REPERFUSION INJURY
Document Type and Number:
WIPO Patent Application WO/2021/136226
Kind Code:
A1
Abstract:
Applications of iminostilbene in preparing a medicament for treating a cardiovascular disease, specifically, cardiac cerebral ischemia/reperfusion injury. Iminostilbene is capable of reducing three myocardial enzymes and inflammatory factors during ischemia reperfusion and reduces apoptosis during ischemia reperfusion.
Inventors:
SUN XIAOBO (CN)
SUN GUIBO (CN)
LU SHAN (CN)
XU XUDONG (CN)
TIAN YU (CN)
SUN GUIBO (CN)
LU SHAN (CN)
XU XUDONG (CN)
TIAN YU (CN)
Application Number:
PCT/CN2020/140577
Publication Date:
July 08, 2021
Filing Date:
December 29, 2020
Export Citation:
Assignee:
CHINESE ACADEMY OF MEDICAL SCIENCES INST OF MEDICINAL PLANT DEVELOPMENT (CN)
International Classes:
A61K31/55; A61P9/00; A61P9/10
Domestic Patent References:
| WO2000069794A2 | 2000-11-23 |
Foreign References:
| CN110946868A | 2020-04-03 | |||
| CN103209699A | 2013-07-17 |
Other References:
LU SHAN, YU TIAN, YUN LUO, XUDONG XU, WENXIU GE, GUIBO SUN, XIAOBO SUN: "Iminostilbene, a novel small-molecule modulator of PKM2, suppresses macrophage inflammation in myocardial ischemia-reperfusion injury", JOURNAL OF ADVANCED RESEARCH, vol. 29, 9 September 2020 (2020-09-09), pages 83 - 94, XP055826416, DOI: 10.1016/j.jare.2020.09.001
XIAO QINGPING, LIU JIANWEN;ZHANG MINHONG;LI FUHUAN;GUO DONG: "Effect of Dibenzazepines Injection on Pulmonary Hypertension in Ｒats", HERALD OF MEDICINE, HUAZHONG KEJI DAXUE TONGJI YIXUEYUAN FUSHU TONGJI YIYUAN, CN, vol. 34, no. 12, 1 December 2015 (2015-12-01), CN, pages 1576 - 1579, XP055828257, ISSN: 1004-0781
GREWAL AMARJOT KAUR, JAGGI AMTESHWAR SINGH, RANA AVTAR CHAND, SINGH NIRMAL: "Effect of Neurosteroid Modulation on Global Ischaemia-Reperfusion-Induced Cerebral Injury in Mice", KOREAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, KOREAN PHYCOLIGICAL SOCIETY, SEOUL, KR, vol. 17, no. 6, 1 December 2013 (2013-12-01), KR, pages 485 - 491, XP055826417, ISSN: 1226-4512, DOI: 10.4196/kjpp.2013.17.6.485
MOOSMANN B, ET AL.: "PROTECTIVE ACTIVITY OF AROMATIC AMINES AND IMINES AGAINST OXIDATIVE NERVE CELL DEATH", BIOLOGICAL CHEMISTRY, WALTER DE GRUYTER GMBH & CO., BERLIN, DE, vol. 382, no. 11, 1 November 2001 (2001-11-01), BERLIN, DE, pages 1601 - 1612, XP009062916, ISSN: 1431-6730, DOI: 10.1515/BC.2001.195
VIJAY KUMAR, H. ; NAIK, N.: "Synthesis and antioxidant properties of some novel 5H-dibenz[b,f]azepine derivatives in different in vitro model systems", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 45, no. 1, 1 January 2010 (2010-01-01), AMSTERDAM, NL, pages 2 - 10, XP026808462, ISSN: 0223-5234
XIAO QINGPING, LIU JIANWEN;ZHANG MINHONG;LI FUHUAN;GUO DONG: "Effect of Dibenzazepines Injection on Pulmonary Hypertension in Ｒats", HERALD OF MEDICINE, HUAZHONG KEJI DAXUE TONGJI YIXUEYUAN FUSHU TONGJI YIYUAN, CN, vol. 34, no. 12, 1 December 2015 (2015-12-01), CN, pages 1576 - 1579, XP055828257, ISSN: 1004-0781
GREWAL AMARJOT KAUR, JAGGI AMTESHWAR SINGH, RANA AVTAR CHAND, SINGH NIRMAL: "Effect of Neurosteroid Modulation on Global Ischaemia-Reperfusion-Induced Cerebral Injury in Mice", KOREAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, KOREAN PHYCOLIGICAL SOCIETY, SEOUL, KR, vol. 17, no. 6, 1 December 2013 (2013-12-01), KR, pages 485 - 491, XP055826417, ISSN: 1226-4512, DOI: 10.4196/kjpp.2013.17.6.485
MOOSMANN B, ET AL.: "PROTECTIVE ACTIVITY OF AROMATIC AMINES AND IMINES AGAINST OXIDATIVE NERVE CELL DEATH", BIOLOGICAL CHEMISTRY, WALTER DE GRUYTER GMBH & CO., BERLIN, DE, vol. 382, no. 11, 1 November 2001 (2001-11-01), BERLIN, DE, pages 1601 - 1612, XP009062916, ISSN: 1431-6730, DOI: 10.1515/BC.2001.195
VIJAY KUMAR, H. ; NAIK, N.: "Synthesis and antioxidant properties of some novel 5H-dibenz[b,f]azepine derivatives in different in vitro model systems", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 45, no. 1, 1 January 2010 (2010-01-01), AMSTERDAM, NL, pages 2 - 10, XP026808462, ISSN: 0223-5234
Attorney, Agent or Firm:
SUNSHINE INTELLECTUAL PROPERTY INTERNATIONAL CO., LTD. (CN)
Download PDF: