Title:
APTAMER CAPABLE OF BINDING TO HGF RECEPTOR
Document Type and Number:
WIPO Patent Application WO/2016/039371
Kind Code:
A1
Abstract:
An aptamer which comprises a polynucleotide selected from polynucleotides (a) to (c) and can bind to an HGF receptor to exhibit an activity of inhibiting the binding of HGF to the HGF receptor. (a) A polynucleotide which comprises the nucleotide sequence represented by SEQ ID NO: 1; (b) a polynucleotide which comprises a nucleotide sequence produced by deleting, substituting, inserting and/or adding one to several nucleotides in the nucleotide sequence represented by SEQ ID NO: 1; and (c) a polynucleotide which comprises a nucleotide sequence having a 80% or higher sequence identity to the nucleotide sequence represented by SEQ ID NO: 1.
Inventors:
SANDO SHINSUKE (JP)
UEKI RYOSUKE (JP)
UEKI RYOSUKE (JP)
Application Number:
PCT/JP2015/075581
Publication Date:
March 17, 2016
Filing Date:
September 09, 2015
Export Citation:
Assignee:
UNIV TOKYO (JP)
International Classes:
C12N15/115
Domestic Patent References:
| WO2012076190A1 | 2012-06-14 |
Foreign References:
| US20130129718A1 | 2013-05-23 |
Other References:
UEKI RYOSUKE ET AL.: "DNA aptamers for receptor signaling inhibition", PROGRAM ABST. INT. SYMP. NUCLEIC ACIDS CHEM., vol. 40, 2013, pages 252 - 253
UEKI RYOSUKE ET AL.: "Control of receptor activity by synthetic molecules (2): Approaches for affinity improvement of DNA aptamer", DAI 95 KAI ANNUAL MEETING OF THE CHEMICAL SOCIETY OF JAPAN IN SPRING (2015) KOEN YOKOSHU, 11 March 2015 (2015-03-11), pages 2J5 - 13
KANDA NAOTO ET AL.: "Control of receptor activity by synthetic molecules (1): Efforts toward efficient receptor activation by DNA aptamer", DAI 95 KAI ANNUAL MEETING OF THE CHEMICAL SOCIETY OF JAPAN IN SPRING (2015) KOEN YOKOSHU, 11 March 2015 (2015-03-11), pages 2J5 - 12
UEKI RYOSUKE ET AL.: "Control of receptor activity by synthetic molecules (2): Approaches for affinity improvement of DNA aptamer", DAI 95 KAI ANNUAL MEETING OF THE CHEMICAL SOCIETY OF JAPAN IN SPRING (2015) KOEN YOKOSHU, 11 March 2015 (2015-03-11), pages 2J5 - 13
KANDA NAOTO ET AL.: "Control of receptor activity by synthetic molecules (1): Efforts toward efficient receptor activation by DNA aptamer", DAI 95 KAI ANNUAL MEETING OF THE CHEMICAL SOCIETY OF JAPAN IN SPRING (2015) KOEN YOKOSHU, 11 March 2015 (2015-03-11), pages 2J5 - 12
Attorney, Agent or Firm:
TANAI Sumio et al. (JP)
Sumio Tanai (JP)
Sumio Tanai (JP)
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