Title:
APTAMER FOR NGF AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2010/035725
Kind Code:
A1
Abstract:
Disclosed are: an aptamer having an inhibitory activity on NGF; a complex comprising an aptamer having an activity to bind to NGF or having an inhibitory activity on NGF and a functional substance (e.g., an affinity substance, a labeling substance, an enzyme, a drug delivery medium, a drug); a pharmaceutical agent, a diagnostic agent and a labeling agent each of which comprises an aptamer having an activity to bind to NGF or having an inhibitory activity on NGF or comprises a complex comprising the aptamer and a functional substance; and others.
Inventors:
JIN LING (JP)
MIYAKAWA SHIN (JP)
FUJIWARA MASATOSHI (JP)
NAKAMURA YOSHIKAZU (JP)
HIRAMATSU HISANAO (JP)
MIYAKAWA SHIN (JP)
FUJIWARA MASATOSHI (JP)
NAKAMURA YOSHIKAZU (JP)
HIRAMATSU HISANAO (JP)
Application Number:
PCT/JP2009/066457
Publication Date:
April 01, 2010
Filing Date:
September 18, 2009
Export Citation:
Assignee:
RIBOMIC INC (JP)
SHIONOGI & CO (JP)
JIN LING (JP)
MIYAKAWA SHIN (JP)
FUJIWARA MASATOSHI (JP)
NAKAMURA YOSHIKAZU (JP)
HIRAMATSU HISANAO (JP)
SHIONOGI & CO (JP)
JIN LING (JP)
MIYAKAWA SHIN (JP)
FUJIWARA MASATOSHI (JP)
NAKAMURA YOSHIKAZU (JP)
HIRAMATSU HISANAO (JP)
International Classes:
C12N15/09; C07K1/22; C12Q1/68
Domestic Patent References:
| WO2004073653A2 | 2004-09-02 | |||
| WO2004096122A2 | 2004-11-11 | |||
| WO2004032870A2 | 2004-04-22 | |||
| WO2005000194A2 | 2005-01-06 | |||
| WO2005111077A2 | 2005-11-24 | |||
| WO2006110883A2 | 2006-10-19 | |||
| WO1991019813A1 | 1991-12-26 | |||
| WO1994008050A1 | 1994-04-14 | |||
| WO1995007364A1 | 1995-03-16 |
Foreign References:
| US5660985A | 1997-08-26 | |||
| US5756703A | ||||
| JP2008244982A | 2008-10-09 |
Other References:
BINKLEY J ET AL.: "RNA ligands to human nerve growth factor", NUCLEIC ACIDS RESEARCH, vol. 23, no. 16, 1995, pages 3198 - 3205, XP002139707
SHIN'YA MIYAGAWA: "Aptamer Iyaku", PROTEIN, NUCLEIC ACID AND ENZYME, vol. 51, 2006, pages 2521 - 2527, XP008139959
BINKLEY J ET AL., NUCLEIC ACIDS RES, vol. 23, 1995, pages 3198 - 3205
SPROAT ET AL., NUCL. ACID. RES., vol. 19, 1991, pages 733 - 738
COTTON ET AL., NUCL. ACID. RES., vol. 19, 1991, pages 2629 - 2635
HOBBS ET AL., BIOCHEMISTRY, vol. 12, 1973, pages 5138 - 5145
ELLINGTON ET AL., NATURE, vol. 346, 1990, pages 818 - 822
TUERK ET AL., SCIENCE, vol. 249, 1990, pages 505 - 510
ELLINGTON, SZOSTAK, NATURE, vol. 346, 1990, pages 818 - 822
TUERK, GOLD, SCIENCE, vol. 249, 1990, pages 505 - 510
M. ZUKER, NUCLEIC ACIDS RES., vol. 31, no. 13, 2003, pages 3406 - 3415
FITZWATER, POLISKY, METHODS ENZYMOL., vol. 267, 1996, pages 275 - 301
BINKLEY J ET AL., NUCLEIC ACIDS RES., vol. 23, 1995, pages 3198
See also references of EP 2354225A4
SHIN'YA MIYAGAWA: "Aptamer Iyaku", PROTEIN, NUCLEIC ACID AND ENZYME, vol. 51, 2006, pages 2521 - 2527, XP008139959
BINKLEY J ET AL., NUCLEIC ACIDS RES, vol. 23, 1995, pages 3198 - 3205
SPROAT ET AL., NUCL. ACID. RES., vol. 19, 1991, pages 733 - 738
COTTON ET AL., NUCL. ACID. RES., vol. 19, 1991, pages 2629 - 2635
HOBBS ET AL., BIOCHEMISTRY, vol. 12, 1973, pages 5138 - 5145
ELLINGTON ET AL., NATURE, vol. 346, 1990, pages 818 - 822
TUERK ET AL., SCIENCE, vol. 249, 1990, pages 505 - 510
ELLINGTON, SZOSTAK, NATURE, vol. 346, 1990, pages 818 - 822
TUERK, GOLD, SCIENCE, vol. 249, 1990, pages 505 - 510
M. ZUKER, NUCLEIC ACIDS RES., vol. 31, no. 13, 2003, pages 3406 - 3415
FITZWATER, POLISKY, METHODS ENZYMOL., vol. 267, 1996, pages 275 - 301
BINKLEY J ET AL., NUCLEIC ACIDS RES., vol. 23, 1995, pages 3198
See also references of EP 2354225A4
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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