Title:
APTAMER TO IL-17 AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2014/148638
Kind Code:
A1
Abstract:
The present invention provides an aptamer that binds with IL-17 to inhibit binding between IL-17 and IL-17 receptor; a complex containing the aptamer and a functional substance (such as a compatible substance, a labeling substance, an enzyme, a drug delivery medium, or a drug); and a medicine, a diagnostic agent, a labeling agent, and the like containing the aptamer or the complex containing the aptamer and a functional substance.
Inventors:
ISHIGURO AKIRA (JP)
NAKAMURA YOSHIKAZU (JP)
HARUTA KAZUHIKO (JP)
OTAKI NATSUKI (JP)
NAKAMURA YOSHIKAZU (JP)
HARUTA KAZUHIKO (JP)
OTAKI NATSUKI (JP)
Application Number:
PCT/JP2014/057919
Publication Date:
September 25, 2014
Filing Date:
March 20, 2014
Export Citation:
Assignee:
UNIV TOKYO (JP)
ZENYAKU KOGYO KK (JP)
ZENYAKU KOGYO KK (JP)
International Classes:
C12N15/00; A61K31/7088; A61K45/00; A61K48/00; A61P29/00; A61P31/00; A61P35/00; A61P37/06; A61P37/08; C07K14/54; C12N15/115; C12Q1/68; G01N33/53
Domestic Patent References:
| WO2010008001A1 | 2010-01-21 | |||
| WO1991019813A1 | 1991-12-26 | |||
| WO1994008050A1 | 1994-04-14 | |||
| WO1995007364A1 | 1995-03-16 | |||
| WO2010008001A1 | 2010-01-21 |
Foreign References:
| US5660985A | 1997-08-26 | |||
| US5756703A | ||||
| JP2011050381A | 2011-03-17 | |||
| JP3626503B2 | 2005-03-09 |
Other References:
K. K. KARLSEN ET AL.: "Locked Nucleic Acid and Aptamers", NUCLEIC ACID THERAPEUTICS, vol. 22, no. 6, 2012, pages 366 - 370, XP055290209
H. ADACHI ET AL.: "Antagonistic RNA aptamer specific to a heterodimeric form of human interleukin-17A/F", BIOCHIMIE, vol. 93, no. 7, 2011, pages 1081 - 1088, XP055002773
A. ISHIGURO ET AL.: "Therapeutic Potential of Anti-Interleukin-17A Aptamer Suppression of Interleukin-17A Signaling and Attenuation of Autoimmunity in Two Mouse Models", ARTHRITIS & RHEUMATISM, vol. 63, no. 2, 2011, pages 455 - 466, XP055047241
L. CHEN ET AL.: "IL -17RA aptamer-mediated repression of IL -6 inhibits synovium inflammation in a murine model of osteoarthritis", OSTEOARTHRITIS AND CARTILAGE, vol. 19, no. 6, 2011, pages 711 - 718, XP028210342
Y. NAKAMURA ET AL.: "RNA plasticity and selectivity applicable to therapeutics and novel biosensor development", GENES TO CELLS, vol. 17, no. 5, 2012, pages 344 - 364, XP055047240
SPROAT ET AL., NUCL. ACID. RES, vol. 19, 1991, pages 733 - 738
COTTON ET AL., NUCL. ACID. RES., vol. 19, 1991, pages 2629 - 2635
HOBBS ET AL., BIOCHEMISTRY, vol. 12, 1973, pages 5138 - 5145
ELLINGTON ET AL., NATURE, vol. 346, 1990, pages 818 - 822
TUERK ET AL., SCIENCE, vol. 249, 1990, pages 505 - 510
ARTHRITIS RHEUM., vol. 63, 2011, pages 455 - 466
JUDITH M. HEALY ET AL., PHARMACEUTICAL RESEARCH, vol. 21, no. 12, December 2004 (2004-12-01), pages 2234 - 2246
BIOCHEMICAL PHARMACOLOGY, vol. 77, 2009, pages 878 - 887
HEATHER L. RIZZO ET AL., J IMMUNOL., vol. 186, 2011, pages 1495 - 1502
A ISHIGURO ET AL., ARTHRITIS RHEUM., vol. 63, 2011, pages 455 - 466
S TOYAMA ET AL., ARTHRITIS RES THER, vol. 12, 2010, pages R92
H. ADACHI ET AL.: "Antagonistic RNA aptamer specific to a heterodimeric form of human interleukin-17A/F", BIOCHIMIE, vol. 93, no. 7, 2011, pages 1081 - 1088, XP055002773
A. ISHIGURO ET AL.: "Therapeutic Potential of Anti-Interleukin-17A Aptamer Suppression of Interleukin-17A Signaling and Attenuation of Autoimmunity in Two Mouse Models", ARTHRITIS & RHEUMATISM, vol. 63, no. 2, 2011, pages 455 - 466, XP055047241
L. CHEN ET AL.: "IL -17RA aptamer-mediated repression of IL -6 inhibits synovium inflammation in a murine model of osteoarthritis", OSTEOARTHRITIS AND CARTILAGE, vol. 19, no. 6, 2011, pages 711 - 718, XP028210342
Y. NAKAMURA ET AL.: "RNA plasticity and selectivity applicable to therapeutics and novel biosensor development", GENES TO CELLS, vol. 17, no. 5, 2012, pages 344 - 364, XP055047240
SPROAT ET AL., NUCL. ACID. RES, vol. 19, 1991, pages 733 - 738
COTTON ET AL., NUCL. ACID. RES., vol. 19, 1991, pages 2629 - 2635
HOBBS ET AL., BIOCHEMISTRY, vol. 12, 1973, pages 5138 - 5145
ELLINGTON ET AL., NATURE, vol. 346, 1990, pages 818 - 822
TUERK ET AL., SCIENCE, vol. 249, 1990, pages 505 - 510
ARTHRITIS RHEUM., vol. 63, 2011, pages 455 - 466
JUDITH M. HEALY ET AL., PHARMACEUTICAL RESEARCH, vol. 21, no. 12, December 2004 (2004-12-01), pages 2234 - 2246
BIOCHEMICAL PHARMACOLOGY, vol. 77, 2009, pages 878 - 887
HEATHER L. RIZZO ET AL., J IMMUNOL., vol. 186, 2011, pages 1495 - 1502
A ISHIGURO ET AL., ARTHRITIS RHEUM., vol. 63, 2011, pages 455 - 466
S TOYAMA ET AL., ARTHRITIS RES THER, vol. 12, 2010, pages R92
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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