Title:
AQUEOUS COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2017/217477
Kind Code:
A1
Abstract:
Provided is a technology whereby a decrease in the contained amount of a halogenated isoquinoline derivative is inhibited in an aqueous composition containing the halogenated isoquinoline derivative and timolol. The aqueous composition comprises: (A) a compound represented by general formula (1) [in the formula, X represents a halogen atom] or a salt thereof, or a solvate thereof; (B) timolol or a salt thereof, or a solvate thereof; and (C) an amino compound.
Inventors:
KUGA HIROAKI (JP)
SAWAI ISAMU (JP)
SAWAI ISAMU (JP)
Application Number:
PCT/JP2017/022034
Publication Date:
December 21, 2017
Filing Date:
June 15, 2017
Export Citation:
Assignee:
KOWA CO (JP)
International Classes:
A61K31/551; A61K9/08; A61K31/5377; A61K47/18; A61P27/02; A61P27/04; A61P43/00
Domestic Patent References:
| WO2016047721A1 | 2016-03-31 |
Other References:
KENJI UEDA ET AL.: "0.0015% Tafluprost/0.5% Timolol Haigo Tengan'eki ( DE -111 Tengan'eki) no Seizai Shoho Sekkei to Rat Gannai Ikosei", JOURNAL OF THE EYE, vol. 30, no. 12, 2013, pages 1761 - 6
"Timoptol Tengan'eki 0.25%/Timoptol Tengan'eki 0.5%, Iryoyo Iyakuhin Tenpu Bunsho", PMDA, August 2014 (2014-08-01), pages 1 - 3
HIDENOBU TANIHARA ET AL.: "Additive Intraocular Pressure- Lowering Effects of the Rho Kinase Inhibitor Ripasudil (K-115) Combined With Timolol or Latanoprost: A Report of 2 Randomized Clinical Trials", JAMA OPHTHALMOLOGY, vol. 133, no. 7, 2015, pages 755 - 761, XP055450634
"Timoptol Tengan'eki 0.25%/Timoptol Tengan'eki 0.5%, Iryoyo Iyakuhin Tenpu Bunsho", PMDA, August 2014 (2014-08-01), pages 1 - 3
HIDENOBU TANIHARA ET AL.: "Additive Intraocular Pressure- Lowering Effects of the Rho Kinase Inhibitor Ripasudil (K-115) Combined With Timolol or Latanoprost: A Report of 2 Randomized Clinical Trials", JAMA OPHTHALMOLOGY, vol. 133, no. 7, 2015, pages 755 - 761, XP055450634
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
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