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Title:
ARALKYL FORMYL-ALKYL PIPERAZINE DERIVATIVES AND THEIR USES AS CEREBRAL NERVE PROTECTIVE AGENT
Document Type and Number:
WIPO Patent Application WO/2003/095437
Kind Code:
A1
Abstract:
The invention relates to aralkyl formyl-alkyl piperazine derivatives, and the use of its compositions in the manufacture of medicaments for preventing or treating cerebral ischemic apoplexy and nerve protection, acting as central system excitable amino acid (N-methy-D-aspartic acid) antagonists (NMDA). The pharmacological experiments show that they display favorable full or ischemic anti-apoplexy activity, nerve protective activity and low side effects.

Inventors:
Jianqi LI. (No.1320 West Beijing Road, Shanghai 0, 20004, CN)
Huang, Liying (No.1320 West Beijing Road, Shanghai 0, 20004, CN)
Min, Yang (No.1320 West Beijing Road, Shanghai 0, 20004, CN)
Weng, Zhijie (No.1320 West Beijing Road, Shanghai 0, 20004, CN)
Zhang, Chunnian (No.1320 West Beijing Road, Shanghai 0, 20004, CN)
Application Number:
PCT/CN2003/000273
Publication Date:
November 20, 2003
Filing Date:
April 16, 2003
Export Citation:
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Assignee:
Shanghai, Institute Pharmaceutical Industry OF. (No.1320 West Beijing Road, Shanghai 0, 20004, CN)
Jianqi LI. (No.1320 West Beijing Road, Shanghai 0, 20004, CN)
Huang, Liying (No.1320 West Beijing Road, Shanghai 0, 20004, CN)
Min, Yang (No.1320 West Beijing Road, Shanghai 0, 20004, CN)
Weng, Zhijie (No.1320 West Beijing Road, Shanghai 0, 20004, CN)
Zhang, Chunnian (No.1320 West Beijing Road, Shanghai 0, 20004, CN)
International Classes:
A61K31/495; A61P25/24; C07D295/192; C07D317/54; (IPC1-7): C07D295/084; A61K31/495; A61P25/24; C07D213/36; C07D215/12; C07D295/108; C07D295/192; C07D309/36; C07D401/12; C07D405/12
Domestic Patent References:
WO1997006802A1
Foreign References:
CN1128026A
CN1293669A
CN87100652A
Other References:
See also references of EP 1553092A1
Attorney, Agent or Firm:
CHINA SINDA INTELLECTUAL PROPERTY LTD. (B11th Floor, Focus Place 19 Financial Street, Beijing 2, 10003, CN)
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