Title:
ARK5
Document Type and Number:
WIPO Patent Application WO/2004/019994
Kind Code:
A1
Abstract:
A novel member of the human AMPK family is identified and named ARK5 (AMPK-Related Kinase 5). In nutritional hunger, ARK5 Akt-dependently supports the survival of cells. A P/ARK cell line constructed by stably transfecting PANC-1, which is a human pancreatic cancer cell line, with ARK5 shows an in vitro metastatic activity twice or more as high as PANC-1 does. In a nude mouse, the P/ARK cell line shows more than 10-fold increase in tumor proliferation 12 weeks after transplantation. The P/ARK cell line shows a significant decrease in the necrotic area in a transplanted tumor nest compared with the parent PANC-1 cells. A nude mouse having the P/ARK cell line transplanted thereto shows obvious intramuscular infiltration and mesenteric metastasis.
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Inventors:
ESUMI HIROYASU (JP)
SUZUKI ATSUSHI (JP)
SUZUKI ATSUSHI (JP)
Application Number:
PCT/JP2003/010435
Publication Date:
March 11, 2004
Filing Date:
August 19, 2003
Export Citation:
Assignee:
JP AGENCYOF NAT CANCER CT (JP)
ORGANIZATION FOR PHARMACEUTICA (JP)
ESUMI HIROYASU (JP)
SUZUKI ATSUSHI (JP)
ORGANIZATION FOR PHARMACEUTICA (JP)
ESUMI HIROYASU (JP)
SUZUKI ATSUSHI (JP)
International Classes:
G01N33/50; A61K31/7088; A61K35/76; A61K35/761; A61K48/00; A61P21/00; A61P25/00; A61P35/00; A61P43/00; C12N5/10; C12N15/09; C12Q1/02; C12Q1/48; C12Q1/68; G01N33/15; G01N33/53; G01N33/566; A61K38/00; (IPC1-7): A61K48/00; A61K31/7088; A61K35/76; A61P21/00; A61P25/00; A61P35/00
Domestic Patent References:
| WO2001059081A2 | 2001-08-16 |
Other References:
KUNIHIKO IZUISHI ET AL.: "Remarkable tolerance of tumor cells to nutrient deprivation: possible new biochemical target for cancer therapy", CANCER RESEARCH, vol. 60, 2000, pages 6201 - 6207, XP002974604
HIROYASU ESUMI ET AL.: "Hypoxia and nitric oxide treatment confer tolerance to glucose starvation in a 5'-AMP-activated protein kinase-dependent manner", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 36, 2002, pages 32791 - 32798, XP002974605
ATSUSHI SUZUKI ET AL.: "Identification of a novel protein kinase mediatin akt survival singaling to the ATM protein", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 1, 3 January 2003 (2003-01-03), pages 48 - 53, XP002974606
ATSUSHI SUZUKI ET AL.: "ARK5 suppresses the cell death induced by nutrient starvation and death receptors via inhibition of caspase 8 activation, but not by chemotherapeutic agents of UV irradiation", ONCOGENE, vol. 22, 2003, pages 6177 - 6182, XP002974607
HIROYASU ESUMI ET AL.: "Hypoxia and nitric oxide treatment confer tolerance to glucose starvation in a 5'-AMP-activated protein kinase-dependent manner", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 36, 2002, pages 32791 - 32798, XP002974605
ATSUSHI SUZUKI ET AL.: "Identification of a novel protein kinase mediatin akt survival singaling to the ATM protein", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 1, 3 January 2003 (2003-01-03), pages 48 - 53, XP002974606
ATSUSHI SUZUKI ET AL.: "ARK5 suppresses the cell death induced by nutrient starvation and death receptors via inhibition of caspase 8 activation, but not by chemotherapeutic agents of UV irradiation", ONCOGENE, vol. 22, 2003, pages 6177 - 6182, XP002974607
Attorney, Agent or Firm:
Shimizu, Hatsushi (1-1-1 Oroshi-mach, Tsuchiura-shi Ibaraki, JP)
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