Title:
AROMATIC AMIDE AS KV2.1 INHIBITOR AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/214980
Kind Code:
A1
Abstract:
The present invention provides a novel aromatic amide as a Kv2.1 inhibitor and a preparation method, pharmaceutical composition, and use thereof. In particular, the present invention relates to an aromatic amide derivative shown in general formula I and a pharmaceutically acceptable salt thereof, a preparation method of the same, a composition comprising one or more such compounds, and a use of such compounds in preparing a drug for preventing and/or treating a disease related to Kv2.1.
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Inventors:
XU BAILING (CN)
WANG XIAOLIANG (CN)
ZHOU JIE (CN)
WANG WEIPING (CN)
LIU DONG (CN)
GUO TINGTING (CN)
WANG XUE (CN)
FENG NAN (CN)
WANG XIAOYU (CN)
XU SHAOFENG (CN)
LI JIANG (CN)
WANG LING (CN)
WANG XIAOLIANG (CN)
ZHOU JIE (CN)
WANG WEIPING (CN)
LIU DONG (CN)
GUO TINGTING (CN)
WANG XUE (CN)
FENG NAN (CN)
WANG XIAOYU (CN)
XU SHAOFENG (CN)
LI JIANG (CN)
WANG LING (CN)
Application Number:
PCT/CN2018/088561
Publication Date:
November 29, 2018
Filing Date:
May 26, 2018
Export Citation:
Assignee:
INST MATERIA MEDICA CAMS (CN)
International Classes:
C07C235/46; A61K31/167; A61P3/10; A61P9/10; A61P25/24; A61P25/28; C07C231/02; C07C237/44
Domestic Patent References:
| WO2010051238A1 | 2010-05-06 |
Foreign References:
| CN102531949A | 2012-07-04 | |||
| CN1205695A | 1999-01-20 | |||
| CN106458910A | 2017-02-22 | |||
| CN102718745A | 2012-10-10 |
Other References:
ZAMBALDO ET AL: "Selective affinity-based probe for oncogenic kinases suitable for live cell imaging", CHEMICAL SCIENCE, vol. 4, no. 5, 13 March 2013 (2013-03-13), pages 2088 - 2092, XP055612723, ISSN: 2041-6539
CHEMICAL ABSTRACTS, 10 April 2013, Columbus, Ohio, US; abstract no. 1427637-40-8
CHEMICAL ABSTRACTS, 10 April 2013, Columbus, Ohio, US; abstract no. 1427637-40-8
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