Title:
AROMATIC AMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL APPLICATIONS THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/157332
Kind Code:
A1
Abstract:
An aromatic amide derivative represented by formula (I), a preparation method therefor, a pharmaceutical composition comprising the derivative, uses thereof as an ROR regulator, and users thereof in preventing or treating inflammatory disease, autoimmune diseases, cancers and other diseases. The aromatic amide derivative has an agitation or anti-agitation activity on ROR. The combined medication of the aromatic amide derivative and a PD-1 antibody can be used in treatment of tumors or cancers.
Inventors:
LU BIAO (CN)
GOU JUN (CN)
ZHANG MINSHENG (CN)
HE FENG (CN)
TAO WEIKANG (CN)
GOU JUN (CN)
ZHANG MINSHENG (CN)
HE FENG (CN)
TAO WEIKANG (CN)
Application Number:
PCT/CN2017/077114
Publication Date:
September 21, 2017
Filing Date:
March 17, 2017
Export Citation:
Assignee:
JIANGSU HENGRUI MEDICINE CO (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D401/14; A61K31/4184; A61P29/00; A61P35/00; A61P37/00; C07D209/12; C07D235/10; C07D235/12; C07D401/06; C07D401/12
Domestic Patent References:
| WO2017024018A1 | 2017-02-09 | |||
| WO2015175845A1 | 2015-11-19 | |||
| WO2013087805A1 | 2013-06-20 | |||
| WO2010051245A1 | 2010-05-06 |
Foreign References:
| CN104640846A | 2015-05-20 | |||
| CN102574836A | 2012-07-11 | |||
| CN101421235A | 2009-04-29 | |||
| US20060148830A1 | 2006-07-06 | |||
| CN1503787A | 2004-06-09 | |||
| CN1553909A | 2004-12-08 | |||
| US4496572A | 1985-01-29 | |||
| CN102498114A | 2012-06-13 |
Other References:
DRAGOVICH, S.P. ET AL.: "Fragment-Based Design of 3-Aminopyridine-Derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 24, 21 December 2013 (2013-12-21), pages 954 - 962, XP028819878, ISSN: 0960-894X
LUO, YU ET AL.: "Synthesis and Anti-Hepatitis B Virus Activity of a Novel Class of Thiazolylbenzimidazole Derivatives", ARCH. PHARM. CHEM. LIFE SCI., vol. 2, 31 December 2001 (2001-12-31), pages 78 - 83, XP055424584
PAGE, D. ET AL.: "Novel Benzimidazole Derivatives as Selective CB2 Agonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 13, 22 May 2008 (2008-05-22), pages 3695 - 3700, XP022716278, ISSN: 0960-894X
AKGUN, H. ET AL.: "Synthesis of Some New Benzimidazole-5(6)-Carboxylic Acids.", J. HETEROCYCLIC CHEM., vol. 32, 31 December 1995 (1995-12-31), pages 1767 - 1773, XP002695652
LUO, YU ET AL.: "Synthesis and Anti-Hepatitis B Virus Activity of a Novel Class of Thiazolylbenzimidazole Derivatives", ARCH. PHARM. CHEM. LIFE SCI., vol. 2, 31 December 2001 (2001-12-31), pages 78 - 83, XP055424584
PAGE, D. ET AL.: "Novel Benzimidazole Derivatives as Selective CB2 Agonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 13, 22 May 2008 (2008-05-22), pages 3695 - 3700, XP022716278, ISSN: 0960-894X
AKGUN, H. ET AL.: "Synthesis of Some New Benzimidazole-5(6)-Carboxylic Acids.", J. HETEROCYCLIC CHEM., vol. 32, 31 December 1995 (1995-12-31), pages 1767 - 1773, XP002695652
Attorney, Agent or Firm:
GE CHENG & CO.,LTD. (CN)
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