Title:
AROMATIC AMIDE DERIVATIVES, MEDICINAL COMPOSITIONS CONTAINING THE SAME, MEDICAL USES OF BOTH
Document Type and Number:
WIPO Patent Application WO/2006/054560
Kind Code:
A1
Abstract:
Aromatic amide derivatives represented by the general formula (I) which have V2 receptor stimulating activity and are useful as preventive or therapeutic agents for diabetes insipidus, night pollakisuria, night enuresis, overactive bladder, and so on; pharmacologically acceptable salts thereof; prodrugs of both, medicinal compositions containing them; and medical uses thereof: (I) wherein R1 is hydrogen or optionally substituted C1-6 alkyl; R2 is hydrogen or C1-6 alkyl; R3 is hydrogen, C1-6 alkyl, or the like; R4, R5 and R6 are each independently hydrogen, halogeno, or the like; R7 is hydrogen, optionally substituted heteroaryl, C3-8 cycloalkyl, optionally substituted amino, or optionally substituted alkoxy; M1 is a single bond, C1-4 alkylene, or the like; and Y is N or CRF (wherein RF is hydrogen, C1-6 alkyl, or the like).
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Inventors:
YOKOYAMA KENJI (JP)
SUZUKI RITSU (JP)
KONDO TATSUHIRO (JP)
KONDO ATSUSHI (JP)
KOBAYASHI HIROAKI (JP)
SUZUKI RITSU (JP)
KONDO TATSUHIRO (JP)
KONDO ATSUSHI (JP)
KOBAYASHI HIROAKI (JP)
Application Number:
PCT/JP2005/020970
Publication Date:
May 26, 2006
Filing Date:
November 15, 2005
Export Citation:
Assignee:
KISSEI PHARMACEUTICAL (JP)
YOKOYAMA KENJI (JP)
SUZUKI RITSU (JP)
KONDO TATSUHIRO (JP)
KONDO ATSUSHI (JP)
KOBAYASHI HIROAKI (JP)
YOKOYAMA KENJI (JP)
SUZUKI RITSU (JP)
KONDO TATSUHIRO (JP)
KONDO ATSUSHI (JP)
KOBAYASHI HIROAKI (JP)
International Classes:
C07D243/14; A61K31/5513; A61P13/02; A61P43/00; C07D401/06; C07D403/06; C07D407/06; C07D409/06; C07D413/06; C07D413/14
Domestic Patent References:
| WO1995034540A1 | 1995-12-21 |
Foreign References:
| JP2004501899A | 2004-01-22 | |||
| JP2003519228A | 2003-06-17 | |||
| JPH0616643A | 1994-01-25 |
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