Title:
AROMATIC COMPOUND, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/161416
Kind Code:
A1
Abstract:
Disclosed are an aromatic compound represented by formula I, and a pharmaceutically acceptable salt, stereoisomer, tautomer, or isotopic compound thereof. The compound has high P2X4 antagonistic activity, good safety, and good pharmacokinetic properties.
Inventors:
LOU JUN (CN)
CHEN YONGKAI (CN)
ZHANG YIHAN (CN)
GUO XIAODAN (CN)
LIU LI (CN)
PENG WEI (CN)
RONG FEI (CN)
WU WEI (CN)
WANG CHAODONG (CN)
CHEN YONGKAI (CN)
ZHANG YIHAN (CN)
GUO XIAODAN (CN)
LIU LI (CN)
PENG WEI (CN)
RONG FEI (CN)
WU WEI (CN)
WANG CHAODONG (CN)
Application Number:
PCT/CN2022/074136
Publication Date:
August 04, 2022
Filing Date:
January 27, 2022
Export Citation:
Assignee:
WUHAN LL SCIENCE AND TECH DEVELOPMENT CO LTD (CN)
International Classes:
C07C311/46; A61K31/145; A61P1/00; A61P9/00; A61P11/00; A61P13/00; A61P15/00; A61P25/00; A61P25/06; A61P27/00; A61P35/00
Domestic Patent References:
| WO2018104305A1 | 2018-06-14 | |||
| WO2018210729A1 | 2018-11-22 | |||
| WO2018104307A1 | 2018-06-14 |
Foreign References:
| CN107848974A | 2018-03-27 | |||
| CN109415321A | 2019-03-01 | |||
| CN111511720A | 2020-08-07 |
Other References:
STEFAN WERNER, STEFANIE MESCH, ROMAN C. HILLIG, ANTONIUS TER LAAK, JULIE KLINT, IOANA NEAGOE, ALEXIS LAUX-BIEHLMANN, HENRIK DAHLL&: "Discovery and Characterization of the Potent and Selective P2X4 Inhibitor N -[4-(3-Chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide (BAY-1797) and Structure-Guided Amelioration of Its CYP3A4 Induction Profile", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 62, no. 24, 26 December 2019 (2019-12-26), US , pages 11194 - 11217, XP055743615, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.9b01304
Attorney, Agent or Firm:
BEIJING ORIGINTELLIGENCE IP LAW FIRM (CN)
Download PDF: