Title:
AROMATIC DERIVATIVES AS ANTI-MALARIAL
Document Type and Number:
WIPO Patent Application WO/2016/063301
Kind Code:
A3
Abstract:
The present invention discloses anti-malarial compound of formula (I) Formula (I) wherein, X is selected from O or NH; R1, R2, R3, R4 and R5 is selected from H or OMe or CH3, -CH2-O-CH2- or -CH=CH-CH=CH-; Y is selected from O or NH and R6, R7 is selected from the following compounds: or pharmaceutically acceptable salts thereof, process for preparation and a pharmaceutical composition containing the same.
Inventors:
BHATTACHARYA ASISH KUMAR (IN)
ARATIKATLA ESWAR KUMAR (IN)
SRIVASTAVA KUMKUM (IN)
MANHAS ASHAN (IN)
ARATIKATLA ESWAR KUMAR (IN)
SRIVASTAVA KUMKUM (IN)
MANHAS ASHAN (IN)
Application Number:
PCT/IN2015/050140
Publication Date:
June 16, 2016
Filing Date:
October 21, 2015
Export Citation:
Assignee:
COUNCIL SCIENT IND RES (IN)
International Classes:
A61K31/16; C07C233/00; A61K31/22; A61K31/357; A61K31/695; A61P33/00; C07C57/00; C07C59/00; C07C235/00; C07D317/60; C07F7/08
Domestic Patent References:
| WO1999002150A1 | 1999-01-21 |
Other References:
KAUR K ET AL: "Antimalarials from nature", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, vol. 17, no. 9, 1 May 2009 (2009-05-01), pages 3229 - 3256, XP026022766, ISSN: 0968-0896, [retrieved on 20090303], DOI: 10.1016/J.BMC.2009.02.050
CASTRO A J ET AL: "The direction of epoxide ring opening in the reaction of styrene oxide with ammonia", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 19, 1 January 1954 (1954-01-01), pages 1444 - 1448, XP002101471, ISSN: 0022-3263, DOI: 10.1021/JO01374A006
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; SANTANIELLO, ENZO ET AL: "Selective lipase-catalyzed preparation of diol monobenzoates by transesterification and alcoholysis reactions in organic solvents", XP002753592, retrieved from STN Database accession no. 2006:518014
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; BALLA, E.: "Certain aryl glycols", XP002753593, retrieved from STN Database accession no. 1934:28513
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; TIAN, XIN ET AL: "Enantioselective production of (S)-1-phenyl-1,2-ethanediol from dicarboxyesters by recombinant Bacillus subtilis esterase", XP002753594, retrieved from STN Database accession no. 2011:1185956
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; CATTANEO, A.: "Chlorination of acridine in sunlight", XP002753595, retrieved from STN Database accession no. 1958:65859
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; YAYLI, NURETTIN: "Isolation and characterization of dibenzoated aromatic compounds", XP002753596, retrieved from STN Database accession no. 1994:557326
CARLO ANCHISI ET AL: "Studies on the synthesis of heterocyclic compounds. VII. Action of acyl halides on heterocyclic compounds containing the O-M-O (M P, As, Sb) bond in the ring", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 19, no. 1, 1 January 1982 (1982-01-01), US, pages 141 - 144, XP055245335, ISSN: 0022-152X, DOI: 10.1002/jhet.5570190127
CASTRO A J ET AL: "The direction of epoxide ring opening in the reaction of styrene oxide with ammonia", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 19, 1 January 1954 (1954-01-01), pages 1444 - 1448, XP002101471, ISSN: 0022-3263, DOI: 10.1021/JO01374A006
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; SANTANIELLO, ENZO ET AL: "Selective lipase-catalyzed preparation of diol monobenzoates by transesterification and alcoholysis reactions in organic solvents", XP002753592, retrieved from STN Database accession no. 2006:518014
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; BALLA, E.: "Certain aryl glycols", XP002753593, retrieved from STN Database accession no. 1934:28513
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; TIAN, XIN ET AL: "Enantioselective production of (S)-1-phenyl-1,2-ethanediol from dicarboxyesters by recombinant Bacillus subtilis esterase", XP002753594, retrieved from STN Database accession no. 2011:1185956
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; CATTANEO, A.: "Chlorination of acridine in sunlight", XP002753595, retrieved from STN Database accession no. 1958:65859
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; YAYLI, NURETTIN: "Isolation and characterization of dibenzoated aromatic compounds", XP002753596, retrieved from STN Database accession no. 1994:557326
CARLO ANCHISI ET AL: "Studies on the synthesis of heterocyclic compounds. VII. Action of acyl halides on heterocyclic compounds containing the O-M-O (M P, As, Sb) bond in the ring", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 19, no. 1, 1 January 1982 (1982-01-01), US, pages 141 - 144, XP055245335, ISSN: 0022-152X, DOI: 10.1002/jhet.5570190127
Attorney, Agent or Firm:
REMFRY & SAGAR (Remfry House at the Millenium PlazaSector 27, Gurgaon 9, Haryana, IN)
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