Title:
AROMATIC HETEROCYCLIC COMPOUND AND INTERMEDIATE, PHARMACEUTICAL COMPOSITION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/222005
Kind Code:
A1
Abstract:
The present invention belongs to the technical field of medicines, and relates to a class of aromatic heterocyclic compounds serving as an LRRK2 inhibitor. The present invention provides a class of compounds with a novel structure, which have a structure represented by formula (K), and provides a new direction for the development of LRRK2 inhibitor drugs. In-vitro enzyme and cell activity inhibition activity research shows that the compounds all have a relatively strong inhibitory effect and can be promising compounds for preventing or treating LRRK2-mediated diseases.
Inventors:
SONG YUNLONG (CN)
LIU TIANQI (CN)
DING XIANGFENG (CN)
JU JIE (CN)
MIAO XINYUAN (CN)
WANG KEZHU (CN)
WANG DISHA (CN)
KOU HONGYAN (CN)
LU KAI (CN)
ZHAO LIANG (CN)
LEI XIANG (CN)
LIU TIANQI (CN)
DING XIANGFENG (CN)
JU JIE (CN)
MIAO XINYUAN (CN)
WANG KEZHU (CN)
WANG DISHA (CN)
KOU HONGYAN (CN)
LU KAI (CN)
ZHAO LIANG (CN)
LEI XIANG (CN)
Application Number:
PCT/CN2023/094659
Publication Date:
November 23, 2023
Filing Date:
May 17, 2023
Export Citation:
Assignee:
INNOVSTONE THERAPEUTICS LTD (CN)
International Classes:
C07D487/22; A61P25/16; A61P25/28; C07D487/08; C07D498/18
Domestic Patent References:
| WO2021224320A1 | 2021-11-11 | |||
| WO2022194976A1 | 2022-09-22 |
Foreign References:
| CN110891954A | 2020-03-17 | |||
| US20160031905A1 | 2016-02-04 | |||
| US20230144725A1 | 2023-05-11 | |||
| CN107108641A | 2017-08-29 | |||
| US20140206683A1 | 2014-07-24 | |||
| CN113164475A | 2021-07-23 |
Attorney, Agent or Firm:
LINDA LIU & PARTNERS (CN)
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