Title:
AROMATIC HETEROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/088957
Kind Code:
A1
Abstract:
Disclosed are a novel aromatic heterocyclic compound as an ATX (Autotaxin) inhibitor, a pharmaceutical composition containing the compound, and a use of the compound and the composition in treatment of a disease having a pathological characteristic of increased ATX expression in a mammal, wherein the compound has a structure represented by formula (I) or (II), or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, tautomer, nitrogen oxide, metabolite, prodrug, or mixture thereof: wherein, R 1a, R 2, R 3, R 6, Cy 1, Cy 2, Y 1, Y 2, Z and t all have the definitions described in the present disclosure.
Inventors:
ZHANG JIANCUN (CN)
ZOU QINGAN (CN)
CHEN YANWEI (CN)
KANG NING (CN)
ZHANG LIJUN (CN)
HU YANG (CN)
YOU HUAJIN (CN)
XIAO XUEBING (CN)
ZOU QINGAN (CN)
CHEN YANWEI (CN)
KANG NING (CN)
ZHANG LIJUN (CN)
HU YANG (CN)
YOU HUAJIN (CN)
XIAO XUEBING (CN)
Application Number:
PCT/CN2020/126996
Publication Date:
May 14, 2021
Filing Date:
November 06, 2020
Export Citation:
Assignee:
GUANGZHOU HENOVCOM BIOSCIENCE CO LTD (CN)
International Classes:
A61K31/433; A61K31/4164; A61K31/4188; A61K31/4353; A61K31/437; A61K31/438; A61K31/439; A61K31/4535; A61K31/454; A61P1/16; A61P3/00; A61P9/00; A61P25/00; A61P29/00; A61P35/00; A61P37/06; C07D513/04; C07D519/00
Foreign References:
| CN110526929A | 2019-12-03 | |||
| CN105339370A | 2016-02-17 | |||
| CN105143221A | 2015-12-09 | |||
| CN110156772A | 2019-08-23 | |||
| CN109384803A | 2019-02-26 | |||
| CN104903327A | 2015-09-09 | |||
| CN105143218A | 2015-12-09 |
Other References:
NICOLAS DESROY, HOUSSEMAN CHRISTOPHER, BOCK XAVIER, JONCOUR AGNÈS, BIENVENU NATACHA, CHEREL LAËTITIA, LABEGUERE VIRGINIE, RONDET E: "Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2- a ]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary F", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 60, no. 9, 11 May 2017 (2017-05-11), US, pages 3580 - 3590, XP055517574, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.7b00032
AGNÈS JONCOUR, DESROY NICOLAS, HOUSSEMAN CHRISTOPHER, BOCK XAVIER, BIENVENU NATACHA, CHEREL LAËTITIA, LABEGUERE VIRGINIE, PEIXOTO : "Discovery, Structure–Activity Relationship, and Binding Mode of an Imidazo[1,2- a ]pyridine Series of Autotaxin Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 60, no. 17, 21 July 2017 (2017-07-21), US, pages 7371 - 7392, XP055517662, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.7b00647
AGNÈS JONCOUR, DESROY NICOLAS, HOUSSEMAN CHRISTOPHER, BOCK XAVIER, BIENVENU NATACHA, CHEREL LAËTITIA, LABEGUERE VIRGINIE, PEIXOTO : "Discovery, Structure–Activity Relationship, and Binding Mode of an Imidazo[1,2- a ]pyridine Series of Autotaxin Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 60, no. 17, 21 July 2017 (2017-07-21), US, pages 7371 - 7392, XP055517662, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.7b00647
Attorney, Agent or Firm:
GUANGZHOU SINO PATENT & TRADEMARK AGENT CO., LTD. (CN)
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