Title:
AROMATIC HETEROCYCLIC COMPOUNDS AND THEIR APPLICATION IN PHARMACEUTICALS
Document Type and Number:
WIPO Patent Application WO/2015/090233
Kind Code:
A1
Abstract:
Provided herein are novel aromatic heterocyclic compounds or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, and their uses for treating Alzheimer's disease. Also provided herein are pharmaceutical compositions containing such compounds, and methods for using such compounds or pharmaceutical compositions thereof to treat Alzheimer's disease.
Inventors:
ZHANG YINGJUN (CN)
JIN CHUANFEI (CN)
ZHONG WENHE (CN)
ZHANG JI (CN)
GAO LI (CN)
CHEN KANGZHI (CN)
JIN CHUANFEI (CN)
ZHONG WENHE (CN)
ZHANG JI (CN)
GAO LI (CN)
CHEN KANGZHI (CN)
Application Number:
PCT/CN2014/094428
Publication Date:
June 25, 2015
Filing Date:
December 19, 2014
Export Citation:
Assignee:
SUNSHINE LAKE PHARMA CO LTD (CN)
International Classes:
C07D401/12; A61K31/437; A61P25/00; C07D413/12
Domestic Patent References:
| WO2010002802A1 | 2010-01-07 | |||
| WO2010011546A2 | 2010-01-28 | |||
| WO2009023844A2 | 2009-02-19 | |||
| WO2008101247A2 | 2008-08-21 | |||
| WO2008147812A2 | 2008-12-04 | |||
| WO2007098418A1 | 2007-08-30 | |||
| WO2010008832A1 | 2010-01-21 | |||
| WO2010024980A1 | 2010-03-04 | |||
| WO2002098878A1 | 2002-12-12 | |||
| WO2008101247A2 | 2008-08-21 | |||
| WO2008147812A2 | 2008-12-04 | |||
| WO2009023844A2 | 2009-02-19 | |||
| WO2010002802A1 | 2010-01-07 | |||
| WO2010008832A1 | 2010-01-21 | |||
| WO2010011546A2 | 2010-01-28 | |||
| WO2010024980A1 | 2010-03-04 |
Other References:
B.L. ROTH ET AL., J. PHARMACOL. EXP. THER, vol. 268, 1994, pages 1403 - 14120
D. R. SIBLEY ET AL., MOL. PHARMACOL, vol. 43, 1993, pages 320 - 327
A.J. SLEIGHT ET AL., NEUROTRANSMISSION, vol. 11, 1995, pages 1 - 5
A. J. SLEIGHT ET AL., SEROTONIN ID RESEARCH ALERT., vol. 2, no. 3, 1997, pages 115 - 118
DAWSON, L. A.NGUYEN, H. Q.LI, P., BRITISH JOURNAL OF PHARMACOLOGY, vol. 130, no. 1, 2000, pages 23 - 26
ROGERS, D. C.HATCHER, P. D.HAGAN, J. J., SOCIETY OFNEUROSCIENCE, vol. 26, 2000, pages 680
ERNST, M.ZAMETKIN, A. J.MATOCHIK, J. H.JONS, P. A.COHEN, R. M., JOURNAL OF NEUROSCIENCE, vol. 18, no. 15, 1998, pages 5901 - 5907
BENTLEY ET AL., BR. J. PHARMAC., 1999
BENTLY ET AL., J. PSYCHOPHARMACOL., 1997, pages 255
WOOLEY ET AL., NEUROPHARMACOLOGY, vol. 41, 2001, pages 210 - 129
DODDAREDDY ET AL., BIOORG. MED. CHEM., vol. 12, no. 14, 2004, pages 3815 - 24
GLENNON ET AL., J. MED. CHEM., vol. 46, no. 14, 2003, pages 2795 - 812
BROMIDGE ET AL., BIOORG. MED. CHEM. LETT., vol. 11, no. 1, 2001, pages 55 - 8
ELIEL, E.WILEN, S.: "Stereochemistry of Organic Compounds", 1994, JOHN WILEY & SONS, INC.
SORRELL ET AL.: "Organic Chemistry", 1999, UNIVERSITY SCIENCE BOOKS
SMITH ET AL.: "Chiral Separation Techniques: A Practical Approach", 2007, WILEY-VCH VERLAG GMBH & CO. KGAA
"McGraw-Hill Dictionary of Chemical Terms", 1984, MCGRAW-HILL BOOK COMPANY
JACQUES ET AL.: "Enantiomers, Racemates and Resolutions", 1981, WILEY INTERSCIENCE
ROBERT E. GAWLEYJEFFREY AUBE: "Principles of Asymmetric Synthesis", 2012, ELSEVIER
ELIEL, E.L.: "Stereochemistry of Carbon Compounds", 1962, MCGRAW-HILL
WILEN, S.H.: "Tables of Resolving Agents and Optical Resolutions", 1972, UNIV. OF NOTRE DAME PRESS, pages: 268
HIGUCHI ET AL.: "Pro-drugs as Novel Delivery Systems", THE A.C.S. SYMPOSIUM SERIES, vol. 14
"Bioreversible Carriers in Drug Design", 1987, AMERICAN PHARMACEUTICAL ASSOCIATION AND PERGAMON PRESS
RAUTIO ET AL.: "Prodrugs: Design and Clinical Applications", NATURE REVIEW DRUG DISCOVERY, vol. 7, 2008, pages 255 - 270, XP055227338, DOI: 10.1038/nrd2468
HECKER ET AL.: "Prodrugs of Phosphates and Phosphonates", JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, 2008, pages 2328 - 2345, XP008148502, DOI: 10.1021/jm701260b
J. PHARMACOL SCI,, vol. 66, 1977, pages 1 - 19
GREENE ET AL.: "Protective Groups in Organic Synthesis", 1991, JOHN WILEY & SONS
KOCIENSKI ET AL.: "Handbook of Pharmaceutical Excipients", 2005, PHARMACEUTICAL PRESS
"Diagnostic and Statistical Manual of Mental Disorder", 1985, AMERICAN PSYCHIATRIC ASSOCIATION
STAHLWERMUTH: "Handbook of Pharmaceutical Salts: Properties, Selection, and Use", 2002, WILEY-VCH
ANSEL ET AL.: "Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems", 2004, LIPPINCOTT, WILLIAMS & WILKINS
GENNARO ET AL.: "Remington: The Science and Practice of Pharmacy", 1995, LIPPINCOTT, WILLIAMS & WILKINS
D. R. SIBLEY ET AL., MOL. PHARMACOL, vol. 43, 1993, pages 320 - 327
A.J. SLEIGHT ET AL., NEUROTRANSMISSION, vol. 11, 1995, pages 1 - 5
A. J. SLEIGHT ET AL., SEROTONIN ID RESEARCH ALERT., vol. 2, no. 3, 1997, pages 115 - 118
DAWSON, L. A.NGUYEN, H. Q.LI, P., BRITISH JOURNAL OF PHARMACOLOGY, vol. 130, no. 1, 2000, pages 23 - 26
ROGERS, D. C.HATCHER, P. D.HAGAN, J. J., SOCIETY OFNEUROSCIENCE, vol. 26, 2000, pages 680
ERNST, M.ZAMETKIN, A. J.MATOCHIK, J. H.JONS, P. A.COHEN, R. M., JOURNAL OF NEUROSCIENCE, vol. 18, no. 15, 1998, pages 5901 - 5907
BENTLEY ET AL., BR. J. PHARMAC., 1999
BENTLY ET AL., J. PSYCHOPHARMACOL., 1997, pages 255
WOOLEY ET AL., NEUROPHARMACOLOGY, vol. 41, 2001, pages 210 - 129
DODDAREDDY ET AL., BIOORG. MED. CHEM., vol. 12, no. 14, 2004, pages 3815 - 24
GLENNON ET AL., J. MED. CHEM., vol. 46, no. 14, 2003, pages 2795 - 812
BROMIDGE ET AL., BIOORG. MED. CHEM. LETT., vol. 11, no. 1, 2001, pages 55 - 8
ELIEL, E.WILEN, S.: "Stereochemistry of Organic Compounds", 1994, JOHN WILEY & SONS, INC.
SORRELL ET AL.: "Organic Chemistry", 1999, UNIVERSITY SCIENCE BOOKS
SMITH ET AL.: "Chiral Separation Techniques: A Practical Approach", 2007, WILEY-VCH VERLAG GMBH & CO. KGAA
"McGraw-Hill Dictionary of Chemical Terms", 1984, MCGRAW-HILL BOOK COMPANY
JACQUES ET AL.: "Enantiomers, Racemates and Resolutions", 1981, WILEY INTERSCIENCE
ROBERT E. GAWLEYJEFFREY AUBE: "Principles of Asymmetric Synthesis", 2012, ELSEVIER
ELIEL, E.L.: "Stereochemistry of Carbon Compounds", 1962, MCGRAW-HILL
WILEN, S.H.: "Tables of Resolving Agents and Optical Resolutions", 1972, UNIV. OF NOTRE DAME PRESS, pages: 268
HIGUCHI ET AL.: "Pro-drugs as Novel Delivery Systems", THE A.C.S. SYMPOSIUM SERIES, vol. 14
"Bioreversible Carriers in Drug Design", 1987, AMERICAN PHARMACEUTICAL ASSOCIATION AND PERGAMON PRESS
RAUTIO ET AL.: "Prodrugs: Design and Clinical Applications", NATURE REVIEW DRUG DISCOVERY, vol. 7, 2008, pages 255 - 270, XP055227338, DOI: 10.1038/nrd2468
HECKER ET AL.: "Prodrugs of Phosphates and Phosphonates", JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, 2008, pages 2328 - 2345, XP008148502, DOI: 10.1021/jm701260b
J. PHARMACOL SCI,, vol. 66, 1977, pages 1 - 19
GREENE ET AL.: "Protective Groups in Organic Synthesis", 1991, JOHN WILEY & SONS
KOCIENSKI ET AL.: "Handbook of Pharmaceutical Excipients", 2005, PHARMACEUTICAL PRESS
"Diagnostic and Statistical Manual of Mental Disorder", 1985, AMERICAN PSYCHIATRIC ASSOCIATION
STAHLWERMUTH: "Handbook of Pharmaceutical Salts: Properties, Selection, and Use", 2002, WILEY-VCH
ANSEL ET AL.: "Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems", 2004, LIPPINCOTT, WILLIAMS & WILKINS
GENNARO ET AL.: "Remington: The Science and Practice of Pharmacy", 1995, LIPPINCOTT, WILLIAMS & WILKINS
Attorney, Agent or Firm:
TSINGYIHUA INTELLECTUAL PROPERTY LLC (Trade Building Zhaolanyuan, Tsinghua University, Qinghuayuan, Haidian District, Beijing 4, CN)
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