AROMATIC HETEROCYCLIC DERIVATIVE HAVING SEROTONIN RECEPTOR BINDING ACTIVITY

WIPO Patent Application WO/2021/193790

A1

The present invention provides a compound which has a serotonin 5-HT2A receptor inverse agonist effect, a pharmaceutically acceptable salt thereof, and a composition which is for serotonin 5-HT2A receptor inverse agonism and which contains the compound or the salt. Provided is a composition which is for serotonin 5-HT2A receptor inverse agonism and which contains a compound represented by formula (I) or a pharmaceutically acceptable salt thereof. (I) (In formula (I), R1 is a substituted or unsubstituted aromatic heterocyclic group or the like, each R2 is independently a hydrogen atom or the like, each R3 is independently a hydrogen atom or the like, n is 1 or 2, R4 is a substituted or unsubstituted non-aromatic nitrogen-containing heterocyclic group, L is -NR8- or the like, R8 is a hydrogen atom or the like, each R5 is independently a hydrogen atom or the like, each R6 is independently a hydrogen atom or the like, p is 1 or 2, and R7 is a group represented by the other formula shown.) (In the other formula shown, R9 is substituted or unsubstituted alkyloxy or the like, R10 is a hydrogen atom or the like, R11 is halogen or the like, and m is 0 or 1.)

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NAKAHARA KENJI (JP)
FUCHINO KOUKI (JP)
NAGATANI KOTARO (JP)

PCT/JP2021/012446

September 30, 2021

March 25, 2021

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SHIONOGI & CO (JP)

A61K31/435; A61K31/437; A61K31/438; A61K31/4427; A61K31/444; A61K31/4523; A61K31/4535; A61K31/454; A61K31/4545; A61K31/4709; A61K31/4725; A61K31/497; A61K31/501; A61K31/506; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P43/00; C07D401/12; C07D405/12; C07D405/14; C07D409/12; C07D413/12; C07D417/12; C07D471/04; C07D491/056

WO2007124136A1

2007-11-01

CN109111385A	2019-01-01
JP2005533813A	2005-11-10

DATABASE REGISTRY 5 September 2017 (2017-09-05), "(CA INDEX NAME) MF -C23 H32 N4 O SR -Chemical Library Supplier: Aurora Fine Chemicals LC", XP055862510, retrieved from STN Database accession no. 2125438-68-6
DATABASE REGISTRY 7 March 2012 (2012-03-07), "N'-[(4-methoxyphenyl)methyl]-N-(1-methyl-4-piperidinyl)-N-(4- pyridinylmethyl)-", XP055862575, retrieved from STN Database accession no. 1360405-98-6
DATABASE REGISTRY 24 August 2006 (2006-08-24), "Urea, N'-(1,3-benzodioxol-5-ylmethyl)-N-[(5-methyl-2-furanyl)methyl]-N- (2,2,6,6-tetramethyl-4-piperidinyl)-", XP055862580, retrieved from STN Database accession no. 904183-12-6
DATABASE REGISTRY 24 August 2006 (2006-08-24), "Urea, N'-[(4-methoxyphenyl)methyl]-N-(2,2,6,6-tetramethyl-4-piperidinyl)-N- (2-thienylmethyl)-", XP055862592, retrieved from STN Database accession no. 904182-24-7
DATABASE REGISTRY 22 August 2006 (2006-08-22), "Urea, N'-(1,3-benzodioxol-5-ylmethyl)-N-(2,2,6,6-tetramethyl-4- piperidinyl)-N-", XP055862595, retrieved from STN Database accession no. 903212-18-0
DATABASE FILE REGISTRY 22 August 2006 (2006-08-22), "Urea, N'-[(4-methoxyphenyl)methyl]-N-[(5-methyl-2-furanyl)methyl]-N- (2,2,6,6-tetramethyl-4-piperidinyl)-", XP055862601, retrieved from STN Database accession no. 903209-39-2

SUGITA Ken-ichi et al. (JP)

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