The present invention relates to an article for use in a toilet or urinal . The invention also relates to a toilet or urinal , comprising said article . The invention further relates to a method for entertaining users of a toilet or urinal , in which said article is applied . The invention also relates to a method for manufacturing said article . The invention also relates to a computer readable medium, comprising instructions for 3D printing said article .

Introduction

The present invention finds its application in toilets and urinals . It is known that disintegrating blocks containing various components can be used for cleaning, disinfecting and/or deodori zing toilets or urinals . Such disintegrating blocks generally are placed on the bottom surface of a toilet or urinal , or are placed in a holder of some sort and then put under the rim of the toilet bowl or urinal . Once put into place , such a block slowly releases active ingredients and disintegrates into the water . The present invention provides an article that can also be placed or thrown on the bottom surface of a toilet or urinal or be placed on a support device placed in a bottom part of a toilet or urinal , but which serves a fundamentally di f ferent purpose .

Summary of the invention

The present invention relates in one aspect to an article for use in a toilet or urinal , wherein the article comprises a visual trigger which motivates a user of the toilet or urinal to urinate onto said article , and wherein the composition of the article is designed to allow the

"SUBSTITUTE SHEETS RULE 26" user to have the article disintegrated in a single pee when urinating onto the article . The article of the invention relates preferably to article for use in a toilet or urinal , wherein the article comprises a visual trigger which motivates a user of the toilet or urinal to urinate onto said article , and wherein the composition of the article comprises a filler component selected from lactose and mannitol or a combination thereof ; and a binder component selected from a cellulose derivative , a starch derivative or a polyvinyl pyrrolidone , or a combination thereof ; and wherein the article has dimensions designed to allow the user to have the article disintegrated in a single pee when urinating onto the article , wherein a single pee is defined as urinating 175-400 ml urine during 5 - 30 seconds .

In a second aspect the present invention relates to a toilet or urinal , comprising said article placed on a surface intended to directly receive a urine stream from a user of said toilet or urinal .

In accordance with the invention the visual trigger of the article triggers a user of the toilet or urinal to pee onto the article and the composition of said article is designed to allow the user to have the article disintegrated in a single pee when urinating onto the article .

The fact that the article can completely dissolve in a single pee motivates the user to aim or direct his urine flow such to reali ze complete disintegration of the article . This makes urinating fun or even enables a competition when used in public toilets , and thus brings about an entertaining ef fect . The purpose of the invention is therefore in one aspect to provide people , more speci fically males in the age group 15-55 , with a fun moment allowing them to relief themselves on a personally ( dis ) liked character/ person/ team/ ef figy or other .

In this respect the invention also relates to the use of the article of the invention, for entertaining a user of the toilet or urinal in which said article is placed .

"SUBSTITUTE SHEETS RULE 26" In this respect the invention also relates to a method for entertaining users of a toilet or urinal , comprising providing an article containing a visual trigger which motivates a user of the toilet or urinal to urinate onto said article , and wherein the composition of the article is designed to allow the user to have the article disintegrated in a single pee when urinating onto the article , wherein said article is placed on a surface intended to directly receive a urine stream from a user of said toilet or urinal ; and allowing a user to urinate onto said article , such that the article disintegrates in a single pee when urinating onto the article .

The inventors have found that the article according to the invention can very suitably be manufactured by means of 3D printing . Therefore , the invention relates in another aspect to a method for manufacturing the article according the invention, comprising 3D printing said article . In view of this the invention relates in a still further aspect to a computer readable medium, comprising instructions for 3D printing the article according to the invention in accordance with said method for manufacturing . In this regard 3D printing may add an extra dimension to the entertaining ef fect mentioned above, because 3D printing allows to obtain an article with multiple layers with images that may di f fer per layer or layers without image alternated with layers that have images . This way a revealing ef fect can be achieved, so that, for instance , when a user aims and urinates on the article , initially a certain image or text is revealed which was hidden from sight before the user started urinating, after which, upon further urinating the full article fully disintegrates .

Short description of the drawings

Fig . l shows a picture of a 3D printed tablet in accordance with the invention with a visual trigger on the top side ( Fig . lA, showing a view from the top side of the tablet ) which motivates a user of the toilet or urinal to

"SUBSTITUTE SHEETS RULE 26" urinate onto the crosshair on the top side of the tablet , and a bottom side opposite to the top side containing a text for promotional purposes ( Fig . IB showing a view from the bottom side of the tablet ) .

Fig . 2 schematically shows side views of tablets with variations with regard to the design of the tablet edges . In a first design the tablet has sharp edges ( Fig . 2A) . In a second, third and fourth design as shown in Fig . 2 B, C and D, respectively the edges are rounded to various extents .

Fig . 3 A-D show pictures of 3D printed tablets of the designs of Fig . 2A-D, respectively . The upper panel shows a picture of the top side of the tablets . The lower panel shows a picture of the side edges of the tablet .

Detailed description of the invention .

The present invention is based on the finding that article containing a visual trigger which motivates a user of a toilet or urinal to urinate onto said article , and wherein the composition of the article is designed to allow the user to have the article disintegrated in a single pee when urinating onto the article can be used to entertain the user of the toilet or urinal . Another point of view regarding the use of the article according to the invention relates to the use of the article in a marketing method, which is also part of the present disclosure . This method comprises the step of handing out the article according to the invention to a user while collecting personal data of the user . In an embodiment thereof articles according to the invention are packaged as single units which can be provided to a user while collecting user data ( location, frequency of use , time ) . For instance , an article can be provided on the condition that a user of the article submits data via an app of QR like technique . The collected user data represent a value for advertisers . Apart from the visual trigger of the article , additional incentives to persuade a user to submit data may be imple-

"SUBSTITUTE SHEETS RULE 26" mented . Additional incentives in this respect may include pri zes associated with "winning" articles , which may for instance be articles that show an unique colour, pattern and/or message when urinated upon . In this respect, the articles according to the invention can also be used in a contest or lottery method which is also part of the present disclosure . In such a lottery or contest method a pri ze can be won when a user has obtained one or more of the aforementioned winning articles .

The article can be used in a urinal or a toilet . This can be a private or public toilet . The invention is in particular suitable for application in a toilet area at large events such as festivals or at large venues or buildings with many toilet users . These can be traditional toilet bowls , urinals , gutters or any other place or means where people urinate . As mentioned above the invention aims suitably at males in the age group of 15-55 years . This is because these will be the average persons using a urinal , and therefore the article ' s composition and specifications are preferably designed such that an average male between 15 and 55 is capable of disintegrating the article according to the invention by peeing on it . Nevertheless the invention is also suitable for male persons of any other age which are able to urinate while standing up or female or trans persons . In this case the use of a female urination device may be preferred so as to enable urinating while standing up . In this respect the disintegration time of the article may also be adapted to the intended user .

The article according to the invention may be provided in a toilet area, for instance in a bowl and may be disposed into the toilet or urinal by the user . Alternatively, the articles can be provided in a dispenser automatically or manually disposing an article according to the invention before a user starts urinating .

In order to prevent that an article starts disintegrating before a person starts urinating on it and also

"SUBSTITUTE SHEETS RULE 26" because positioning an article in a toilet or urinal can be di f ficult , a small support device may be provided, for instance comprising a suction cup to attach the support device on the bottom or back side of the toilet or urinal . The support device may comprise a flat platform with an optional protruding rim . This allows to position the article in the toilet or urinal in an optimal and stable position so that disintegration only takes place when a person urinates on it and not by flushing water, for instance .

In one embodiment the article may be shaped such that the article itsel f forms the visual trigger . The shape in this respect may be any design that motivates a user of a toilet or urinal to urinate onto said article . For instance the article can be provided in the shape of a person, an animal , a building or a word or phrase that invokes an urge to urinate onto the article .

In a preferred embodiment it is not the shape of the article itsel f that form the visual trigger, but the visual trigger is a picture or text comprised in said article . The visual trigger may for instance be selected from an image selected among popular figures , a logo or brand name selected from the field of entertainment , cartoons , politics , sports , science etc . The article in this embodiment can be provided the shape of a block or tablet , for instance in a square , cylinder, bead, or flat disk, for instance a circular disk . These shapes allow high throughput production against low costs . In order to reali ze a shaped article and for purposes of production, it is preferred that the article in accordance with the invention is composed of a solid material .

A flat tablet is preferred . This allows minimal use of material , while the visual trigger can be maximally exposed to the user of the toilet or urinal . The flat tablet can suitably be a flat disc . Without limitation such a flat disc may have a square , rectangular, elliptic, or circular shape or any other shape . To have the article disintegrated in a single pee when urinating onto the ar-

"SUBSTITUTE SHEETS RULE 26" tide and to keep an entertaining function, the dimensions of the tablet should preferably be chosen such that it takes about 5-30 s of peeing on it to have the tablet completely disintegrated . It is even more preferred that the tablet completely dissolves withing between 5 and 15 seconds of peeing on it to ensure a good dissolving result within the duration of a single pee . These parameters apply in particular to male persons between 15 and 55 . A tablet with a diameter si ze between 10 and 50 mm and a thickness between 2 and 6 mm, such as a diameter si ze of approximately 40 and a thickness of 3 to 5 mm, such as 4 mm, would for instance be suitable for these purposes because the limited diameter allows the tablet to be fully contacted with a urine stream produced by a user . The thickness of the tablet af fects the disintegration behaviour . The thicker the tablet , the longer it takes for a tablet to disintegrate .

It is preferred that the picture or text extends through at least a part of the thickness of the tablet . This way the visual trigger is longer visible to the user urinating on the tablet , which is advantageous for the motivation of the user to urinate onto the tablet . In view of this it , is even more preferred that the picture or text extends through the maj or part of the thickness of the tablet , even more preferably fully through the thickness of the tablet .

For marketing purposes the tablet may comprise a top side containing said visual trigger which motivates a user of the toilet or urinal to urinate onto the top side of the tablet , and a bottom side opposite to the top side containing a text or picture for promotional purposes . Such a text or picture for promotional purposes may for instance be a company or product name or trademark . When urinated upon, the article should fully disintegrate in a single pee when urinating onto the article . An average pee usually comprises a flow of 175-400 ml urine during 5 - 30 seconds . It is therefore preferred that a sin-

"SUBSTITUTE SHEETS RULE 26" gle pee is defined as urinating 175-400 ml urine during 5 - 30 seconds .

Alternatively, the requirement that the article should fully disintegrate in a single pee when urinating onto the article may be defined by way of the urine flow simulation test described in the examples section below which comprises the steps of heating water to 37 ° C, placing the article in a sieve underneath an outlet from which water flows to simulate urinary flow, wherein water is flown over the article at a rate of 10 ml/ s , which corresponds to the lower limits of the urinary flow of an average adult male . Under these circumstances the article should fully disintegrate within 5 - 30 seconds .

As already indicated above , it is even more preferred that the article completely dissolves within between 5 and 15 seconds of peeing on it to ensure that the article dissolves within the duration of a single pee . Disintegration or dissolving the article should be such that 95% of the users urinating onto the article see the article fully disintegrate or dissolve as a result of their own ef fort and not from pre-existing wetness or flushing water in the toilet or urinal . The composition and/or dimensions of the article may therefore be adapted to the type of urinal or toilet , depending on the presence of flushing water .

The tablet must be si zed and shaped in such way that it is easy to throw/position it in most urinals .

In an embodiment wherein a tablet is thrown into a toilet or urinal it may be preferred that a tablet does not end up face down, i . e . with the visual trigger image down . In this case a straight forward coin shape may be extended to include hyperbolic edges and/or slight hyperbole mid points .

In some embodiments it may be preferred that the tablet has a floating capacity, so that is floats on preexisting water/urine in a toilet or urinal . To improve floating capability the bottom may be designed more curved than the top .

"SUBSTITUTE SHEETS RULE 26" The visual trigger may be applied onto or throughout the article in various ways . For instance an article may comprise at least two layers of which at least one top layer contains the visual trigger . This top layer may then be glued to the bottom layer ( s ) , for instance by heatglueing . The top layer ( s ) may be provided as a single sheet with an image or as multiple layers of material with the same image to provide said image throughout the thickness of the article . For instance , in one embodiment the article may comprise multiple layers , including at least one inner layer comprising a visual trigger initially hidden from sight by a covering layer which is closer to the surface of the article compared to said inner layer or at the surface , wherein said visual trigger can be revealed upon urinating onto said covering layer .

Alternatively, the visual trigger may be embossed into a premanufactured article , or glued or printed onto the premanufactured article , wherein the article preferably is a tablet which can be made by a tablet press .

In a preferred embodiment an article with a visual trigger is 3D printed . 3D printing techniques allow an image to be printed throughout at least part of the thickness of an article , such as in particular a tablet , i . e . from bottom to top . For instance , Powder Bed Printing ( PBP ) , including Binder Jetting, Multi Jet Fusion and Selective Laser Sintering ( SLS ) or a combination thereof as exemplary Powder Bed Printing methods may be considered in the context of the present invention as they can be used to create highly porous tablets that can dissolve quickly, also depending on the choice of materials .

As mentioned above , a visual trigger in the form o f an image is preferably present not only on the outer surface of the tablet but also at least partially throughout the thickness of tablet , in order to assure that the image is visible for longer periods of time during the disintegration of the tablet , possibly even allowing changes in the tablet to take place . By tuning the laser settings SLS

"SUBSTITUTE SHEETS RULE 26" is often capable of creating di f ferent shades of brown during the consolidation process . This is caused by the heat generated that in turn can lead to a local colouring of the material similar to the browning of food products when exposed to heat in an oven . In fact , SLS can be used to create images in that way using shades of browning . It would also be possible this way to create the image ( or di f ferent images ) on each layer of the printed obj ect .

In addition to the disintegration speed a further preferred requirement is the presence of a full/multi- colour image on the tablet . In view of this printing may suitably take place using a Powder Bed Printing ( PBP ) device . PBP is more preferred because in contrast to SLS it can be used to create full-colour 3D obj ects using a range of ( typically white ) powder materials in combination with coloured printing inks . The printing process is similar to the creation of colour images using an inkj et document printer . The material requirements for PBP process can be split into two : those pertaining to the powders and those pertaining to the printing liquids (" inks" ) . Besides the requirements for the process , the speci fic envisioned application will pose additional requirements for the materials . This will be explained below, with reference to suitable materials and compositions .

A very suitable PBP printing approach involves Binder Jetting . In Binder Jetting, a printing ink is selectively deposited onto a powder bed, bonding these areas together to form a solid article , such as a tablet , one layer at a time . When the 3D printer has noz zles to deposit printing ink, it is possible to create full-color articles . In this approach, typically first a thin layer of powder is spread over the build platform . Then, a carriage with inkj et nozzles passes over the bed, selectively depositing droplets of a binding agent ( glue ) that bond the powder particles together . In full-colour Binder Jetting, the coloured ink is also deposited during this step . The si ze of each drop is approximately 50 pm in diameter, so good resolution can

"SUBSTITUTE SHEETS RULE 26" be achieved . When the layer is complete , the build platform moves downwards and the blade re-coats the surface . This is repeated until the article is complete . After printing, the article is encapsulated in the powder and is left to cure and gain strength . Then the article is removed from the powder bin and any unbound, excess powder is removed using pressuri zed air .

With respect to the powders the requirements are typically that the powders must be free- flowing and of a particle si ze distribution that matches the layer thicknesses that are being used .

Although printing processes can be carried out under controlled atmosphere , ideally the powders are non- hygroscopic and non-static, nor should they have melting points close to the operating temperatures of the printer ( around room temperature ) as meeting these speci fications will prevent issues with stickiness and powder deposition on printing heads , depositors , etc .

Naturally, in order to achieve consolidation of the powders into a solid 3D obj ect the individual powder particles must be stuck together by means of the ef fect of the printing liquid being deposited . The following routes are preferred options for consolidation .

In a first route the printing liquid can be a gluetype material that makes the particles stick together, without the particles needing to have any sticking characteristics themselves . This route does not really pose any requirements on the powder materials , other than having to be wettable by the printed glue droplets .

In a second route the printing liquid interacts with the powder particles ( or at least with one type of particulate material i f a blend is used) in that it at least partially dissolves the particles , resulting in liquid bridges between the individual particles in which the liquid contains dissolved material . The amount of liquid added will determine the amount of binding and in turn the time it takes for the tablet to dissolve . Upon drying the

"SUBSTITUTE SHEETS RULE 26" particles are stuck together by the now solidi fied previously dissolved material , resulting in a solid obj ect . The degree of dissolution of the powder material in the printing liquid can vary, and the creation of sticky outer surfaces of particles can be enough to make the material stick together . As mentioned, not all the powder material needs to be soluble , as blends can be used that contain filler-type powders and glue-type powders . Naturally enough of the glue-type powder must be present to make the entire 3D obj ect stick together . This route does pose requirements on the material , speci fically on the glue-type powders in that they need to be soluble to some degree in the printing liquid that is being used, allowing them to stick together upon drying .

The type of inks that can be used in the powder printing process may depend on the printing heads that are being employed, as each printing head poses speci fic requirements with respect to the viscosity and surface tension of the liquids . Good results with 3D printing tablets have for instance been achieved with inks based on dyes dissolved in a water/ethanol mixture , for instance in a 70/ 30 volume ratio and using inks in a percentage of 15-30 wt . % with respect to the weight of the powders (binder and filler ) .

When looking at the di fferent types of printing heads that can be used in the context of the present invention these can be divided into two types of single noz zle valves , speci fically passive/non-piezo and piezo-based, and multi-noz zle valve systems . Each of these have their own advantages and disadvantages . The passive single nozzle valves are relatively cheap but have a limited range of fluid properties they can handle . In contrast , the piezo-based single noz zle systems can handle a much broader range of fluids , but are more expensive . Being single nozzle , both systems however are slow with respect to the deposition of a layer of liquid . With regard to speed, multi-noz zle systems are preferred as they can be used for

"SUBSTITUTE SHEETS RULE 26" so-called "single pass" printing (i.e. deposition of a whole layer of droplets in a single pass) .

In a suitable embodiment the tablets are manufactured by 3D printing to have rounded edges instead of sharp edges. This may have advantageous effects on the appearance of a printed tablet.

The materials used for manufacturing the article according to the invention are preferably environmentally safe. Preferably the materials are food grade materials. This way, the article does not harm a person accidently mistaking the article for a piece of candy instead of an article intended for use in a toilet or urinal.

A powder formulation for 3D printing in accordance with the abovementioned second route is typically composed of two basic components, a (polymer) binder and a filler. The binder component may comprise a single binding agent or multiple binding agents. Likewise the filler component may comprise a single filler agent or multiple filler agents. The terms "binder" and "filler" in the context of the present invention may thus refer to a single binder or filler agent or to multiple binder or filler agents. The binder interacts with the print fluid in that it can (at least partially) dissolve in order to bind the rest of the material after drying. The polymer binder fraction in the powder mixtures is typically around 10-30 wt.%, with the rest being filler. Both polymer binder powder and filler powder have to have the right particle size (range) (typically a size D50 of 50-60 pm) , allowing it to be successfully used in the PBP process. Additionally, the particle size will also influence the final resolution and surface roughness of the printed object. In order to improve the disintegration behaviour it is possible to add a disintegrant (microcrystalline cellulose, sodium starch glycolate, etc.) similar to the use of such compounds in pharmaceutical tablets. Alternatively methods to change the disintegration behaviour of the tablet are: changing the ratio of binder: filler (a higher amount of binder re-

"SUBSTITUTE SHEETS RULE 26" suits in longer disintegration time ) ; changing the printing liquid amounts or other printing parameters ( a higher amount of printing liquid results in longer disintegration time ) ; changing the way in which the printing liquid is distributed, including linespacing, droplets/mm; changing layer height ; changing print fluid; changing the design of the tablet ; alone or in any combination .

Suitable fillers and binders may be selected from known binders in the art of tabletting for medical purposes . Commonly used fillers in this respect include lactose , mannitol , sugar and other powders . Commonly used binders include for instance pregelatini zed starch, polyethylene glycol , sugar, maltodextrin, hydroxypropyl cellulose , polyvinyl pyrrolidone , vinylpyrrolidone-vinyl acetate polymer and the like . Sugar ( this term referring herein to consumable sugar ) may act as a binder and a filler in this respect .

Particularly preferred fillers may be selected from lactose and mannitol . These are food grade and can be used in a 3D printing process , and in particular a PBP 3D printing process .

Suitable polymer binders may, without limitation, be selected from a cellulose derivative , a starch derivative or a polyvinyl pyrrolidone compound . Suitable examples of starch derivatives are pregelatini zed starch, starch, dextrin, maltodextrin, and the like . Suitable examples of cellulose derivatives include hydroxypropyl cellulose , methyl cel lulose and the like . Suitable polyvinyl pyrrolidone compounds include polyvinyl pyrrolidone , vinylpyrrol- idone-vinyl acetate copolymers etc . These compounds are food grade and can be used in a 3D printing process , in particular a PBP process .

In view of this , in a suitable embodiment the composition of the article of the invention may comprise a first component selected from lactose and mannitol and a second component selected from a cellulose derivative , a starch derivative or a polyvinyl pyrrolidone compound .

"SUBSTITUTE SHEETS RULE 26" The powder composition for 3D printing may also be dependent on the print fluid ( ink) used . For instance for a water based printing fluid the combinations pregelatini zed starch / lactose , polyethylene glycol / mannitol , sugar / lactose , maltodextrin / lactose , or sugar / maltodextrin may be suitable . On the other hand for a wa- ter/ethanol based printing fluid the combinations pregelatini zed starch / lactose , vinylpyrrolidone-vinyl acetate copolymer / mannitol , polyvinyl pyrrolidone/ mannitol , hydroxypropyl cellulose / mannitol , or polyethylene glycol / sugar may be suitable .

Good results with regard to appearance - as well as image appearance and overall appearance of a printed tablet - and disintegration time were observed when lactose was used as a first component in combination with a cellulose and/or starch derivative . In a preferred embodiment the composition of the article therefore comprises lactose as said first component and a component selected from a cellulose derivative and a starch derivative as said second component . Herein it is preferred that the binder component comprises a cellulose derivative and a starch derivative .

Good balance between appearance , disintegration time was obtained with tablets compri sing lactose and starch, in particular pregelatini zed starch . The combination of lactose and starch performs well and is minimally af fected by the composition of the urine to which it is exposed . I t is noted that the combination of lactose and starch results in a particularly satis fying disintegration behaviour . Namely, during the first seconds of peeing an article with these lactose and starch as main ingredients does not visibly change and only starts to visibly disintegrate after this first short period of time . On the other hand, within 10-30 seconds articles of this composition will be fully disintegrated so that no residues are left behind in the toilet of urinal . The apparent initial stability before disintegration starts to be visible to the person

"SUBSTITUTE SHEETS RULE 26" urinating on it increases the entertaining effect of the article, because said person has to put some effort in successfully peeing the article away, while the reward (disappearance of the article) is usually guaranteed.

It is therefore, preferred that the composition of the article comprises lactose as said first component and a starch, preferably pregelatinized starch as said second component. With regard to these embodiments preferred ratios between first and second component may range from 90:10 to 70:30 (weight: weight) . In a preferred embodiment the composition of the article comprises two main ingredients: lactose as filler in an amount of 70-80 wt . % and starch as a binder in an amount of 20-30 wt.%, with preferred particle sizes of D50 50-60. Higher amounts of starch result in longer disintegration times of the article and vice versa. The above amounts result in a good balance between printability and disintegration time.

In a highly preferred embodiment, the article comprises 70 - 80 weight % of lactose, 15 - 25 weight % of starch and 5 - 10 weight % of cellulose based on the total weight of lactose, cellulose and starch. Herein the particle sizes D50 of the binder and filler preferably range between 50 and 100 pm, preferably between 65-90pm, such as between 70-85 pm, with a maximum size of 125 pm. With these components, ratios and sizes the articles have a very good balance between appearance and disintegration time. In particular, in these ratios the lactose component has been found to contribute to a good printing bed when the articles are produced by printing, the starch component contributed to obtaining a fast drying, firm product, with good visual appearance, with little release of powder during handling and transport, and the cellulose component on its turn contributes to uniform disintegration behaviour, so that the product disintegrates layer wise in an erosive behaviour. This way the visual triggers may remain visible until the article has fully or nearly fully disintegrated, which enhances the fun effect of the article.

"SUBSTITUTE SHEETS RULE 26" Apart from fillers and binders , further compounds may also be included in the article according to the invention, including without limitation flavours or aromas for odour and to render the article edible , surface active compounds and/or disinfectants for a cleaning, or any other additive .

Examples

The following examples show various embodiments of articles for use according to the invention and exemplary methods for manufacturing said articles . The present examples are intended to illustrate the invention and are not intended to limit the scope of the invention .

An investigation was conducted with regard to manufacturing tablets for use in a toilet or urinal , the tablets having visual triggers motivating a user of the toilet or urinal to urinate onto said article , and wherein the composition of the article is designed to allow the user to have the article disintegrated in a single pee when urinating onto the article . Within the context of the present invention the term disintegration may encompass dissolving the material of the article in liquid and/or disintegration into particles small enough to be flushed through a toilet . Full disintegration implies that no tablet residue is left sticking on the surface supporting the tablets .

Tablets were envisaged with a flat surface showing disintegration ideally between 5 and 30 seconds when exposed to a simulated urinary flow .

Test 1

Small circular tablets with a diameter si ze of 15 mm and a thickness of 4 mm were 3D printed using a Powder Bed Printing ( PBP ) device ( ProJet CJP 660 Pro ) based on vari-

"SUBSTITUTE SHEETS RULE 26" ous compositions and printing specifications. The following materials were used:

• Amylogum CLS, starch, D50= 70 pm, Mw low, AVEBE,

• Respitose SV003, lactose, <45 pm 0-40/26%, <63 pm 40- 70/54%, <100 pm 90-100/97%, DEE Pharma

• HPC SLFP, Hydroxy propyl cellulose, D50=80-110 pm, Mw 100.000, Nisso

• Kollidon K25, Polyvinylpyrrolidone, Sigma, product code: 02286

• Kollidon VA64, vinylpyrrolidone-vinyl acetate copolymers, <50 pm max 35%, >250 pm max 7%, Mw 45.000- 75.000, BASF

• Maltodextrin DE19, Aldrich, product code: 419699

• Mannitol, product code: 25311.366, VWR

• Methyl cellulose, sigma-Aldrich, product code:M0262

• Prejel PA5 PH, starch, D10=10 pm, D50=65 pm, D90=156 pm, DEE Pharma

Printing conditions:

• Tablets were printed with 70/30 & 50/50 v/v demi wa- ter/ethanol (+0.05 w/v% blue dye)

• Dye: patent blue V for microscopy (Sigma-Aldrich 20262-76-4)

• Dissolve 0.02 g of dye in 28 mL of demiwater, then add 12 mL of EtOH. Filter (millex 5 pm) the solution, then degas for 5 min in an ultrasonic bath using the degas setting.

• In the formulations ratios of 80/20 were used between two powder components. The ratios are typically based on prior experience with 3D printing of pharmaceutical tablets. Other ratios may also be successful for the purposes of the present invention.

• Linespacing 0.30, 0.35, 0.40, 0.45, 0.50 mm. The linespacing range reflects the amount of liquid (i.e. ink) deposited per surface area. Higher line spacings indicate bigger distances between droplet lines that

"SUBSTITUTE SHEETS RULE 26" are deposited and hence a lower amount of liquid per surface area .

• Tablets diameter = 15 mm, height = 4 mm, layer thickness = 0 . 4 mm

• Tablets removed from powder bed 30 s after print i s finished

• Drying in oven 50 ° C overnight ( optional ) .

Urinary flow simulation test

In order to simulate a person urinating on the tablets water was heated in a water bath to 37 ° C (body temperature ) . Tablets were placed in a sieve underneath the tube from which water could be expelled, simulating the urinary flow . Using a pump, water was flown over the sample at a rate of 10 mL/ s , which corresponds to the lower limits of the urinary flow of an average adult male . Movies were made of the disintegration/dissolution behavior of the various tablets . The required disintegration/dissolution time was reported, as well as the general behavior of the tablet when wetted . Tests results were confirmed on small scale by a urinating person .

"SUBSTITUTE SHEETS RULE 26"

'SUBSTITUTE SHEETS RULE 26'

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Table 1 : Performance of various formulations of tablets in a urinary flow simulation test .

Appearance The tablets produced with the formulations listed in Table 1 were assessed based on their visual appearance wherein tablets with high visibility of print and smooth surface were ranked from 1 - 5 , wherein #1 has the best appearance . The results are shown in Table 2 below :

Table 2 : Top 5 appearance score of tablets .

Dual image printing

'SUBSTITUTE SHEETS RULE 26' With the composition of formulation no. 11 a dual printed tablet with a diameter of 40 mm and a thickness of 4 mm was printed as shown in Fig. 1 with a visual trigger on the top side (Fig.lA) which motivates a user of the toilet or urinal to urinate onto the top side of the tablet, and a bottom side opposite to the top side containing a text for promotional purposes (Fig. IB) . To achieve this, tablets were printed with the f ace/cross-hairs image in the top 6/7 layers and the Latisus logo in the bottom 2 layers, with a blank intermediate layer between the image and the text to avoid that the top image can often be seen through the bottom layers.

Shape of the tablet

The inventors have found that the resolution of the visual trigger can be enhanced by designing the shape of the tablet. In a first design the tablet has sharp edges (Fig. 2A) . In a second, third and fourth design as shown in Fig. 2 B, C and D, respectively the edges are rounded. Fig. 2B shows identical top and bottom rounding. Fig. 2C shows exaggerated rounding of the top. Fig. 2D shows strongly exaggerated rounding of the top. Fig. 3 shows tablets printed with formulation no.11 with sharp edges (Fig.3A) , and according to the abovementioned second, third and fourth design (Fig. 3B-D) . Similar results were obtained with formulations 2 (lactose SV003/ amylogum) and 8 (lactose SV003/ methyl cellulose) . It is clear from Fig. 3 that rounding the edges of the tablet results in improved appearance in terms of visibility of print of the tablet .

Test 2

Tablets were 3D printed using the Binder Jetting approach. The following materials were used:

• Inks based on a dyes dissolved in a water/ethanol mixture in a 70/30 volume ratio.

"SUBSTITUTE SHEETS RULE 26" • Lactose filler (Respitose SV003 (monohydrate lactose ) D50 particle si ze = 61 pm .

• Starch binder (Amylogum CLS ) D50 particle si ze = 70 pm, Mw low .

Printer ink was used in an amount of 15-30 wt . % with respect to the powder portion . Performance of various formulations of tablets was tested in a urinary flow simulation test as described above . Tests results were confirmed on small scale by a urinating person . The results are shown in table 2 below :

Table 2 : Performance of various formulations of Binder Jetting produced tablets in a urinary flow simulation test .

It is particular noted in relation to the lactose/ starch based tablets (both PBP printed and Binder Jetting print-

"SUBSTITUTE SHEETS RULE 26" ed) that during the first seconds of peeing the tablets do not visibly change and only start to visibly disintegrate after this short period of time . On the other hand, within 10-20 seconds tablets of this composition are fully disintegrated so that no residues are left behind in the toilet of urinal . The initial apparent stability of the tablet before disintegration starts to be visible to the person urinating on it increases the entertaining ef fect of the tablet , because said person has to put some ef fort in success fully peeing the tablet away, while the reward ( disappearance of the tablet ) is guaranteed .

Test 3

Tablets were 3D printed using the Binder Jetting approach . The following materials were used :

• Inks based on a dyes dissolved in a water/ethanol mixture in a 70/ 30 volume ratio .

• Lactose filler ( Pharmatose 125 M (monohydrate lactose ) D50 particle si ze = 80 pm .

• Starch binder (Amylogum CLS ) D50 particle si ze = 70 pm, Mw low .

• Cellulose binder (HPC SSL, hydroxypropylcellulose , D50 = 85 pm .

Tests were performed with binder and filler portions containing 70 - 80 wt . % lactose , 15- 25 wt . % starch and 5- 10 wt . % cellulose (powder ) Tablets were made using 4 - 6 g powder and using 1 . 0- 1 . 5 ml ink per tablet . Performance of tablets was tested in a urinary flow simulation test as described above and it was confirmed on small scale by a urinating person that the tablets produced disintegrated completely over a period of 8 to 15 seconds . In addition, the tablets had good visual appearance , with little release of powder during handling and transport , were firm and fast-drying, and had uni form disintegration behaviour, so that the tablet disintegrates layer wise in an erosive behaviour so that visual triggers may remain visible until

"SUBSTITUTE SHEETS RULE 26" the tablet had fully or nearly fully disintegrated, thus enhancing the fun ef fect of the tablet .

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