Title:
ARTIFICIAL BIOPROSTHETIC VALVE AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2021/212787
Kind Code:
A1
Abstract:
An artificial bioprosthetic valve and a preparation method therefor. The artificial bioprosthetic valve comprises a support and a functional biological tissue material attached to the support. The functional biological tissue material is a biological tissue connected to an active group and a functional molecule or group by means of a covalent bond. A functional polymer material is at least one of heparin, hyaluronic acid, polyethylene glycol, argatroban, hirudin, bivalirudin, fucoidan, ACH11 polypeptide, antithrombase-III, APC, sodium citrate, albumin, urokinase, a hydroxy group, a sulfonic acid group, sulfonic acid phenyl, and an amphoteric ion. High-grafting-degree active groups and functional molecules or groups are covalently modified on the surface of the bioprosthetic valve, so that the anti-thrombotic and anti-calcification functions are improved; the prepared artificial bioprosthetic valve does not contain aldehyde group residues, is good in biocompatibility, proper in mechanical property and good in stability, and can satisfy the use performance requirements of transcatheter interventional bioprosthetic valves.
Inventors:
WANG YUNBING (CN)
YANG FAN (CN)
GUO GAOYANG (CN)
YANG FAN (CN)
GUO GAOYANG (CN)
Application Number:
PCT/CN2020/123352
Publication Date:
October 28, 2021
Filing Date:
October 23, 2020
Export Citation:
Assignee:
UNIV SICHUAN (CN)
International Classes:
A61F2/24; A61L27/36; A61L27/54; A61L33/00; A61L33/06; A61L33/10
Foreign References:
| CN105682609A | 2016-06-15 | |||
| CN106730051A | 2017-05-31 | |||
| CN111494717A | 2020-08-07 | |||
| US9272075B2 | 2016-03-01 | |||
| CN109481085A | 2019-03-19 | |||
| JPS6253666A | 1987-03-09 | |||
| US6702851B1 | 2004-03-09 |
Other References:
WEI-HSUAN KUO, MENG-JIY WANG, HSIU-WEN CHIEN, TA-CHIN WEI, CHIAPYNG LEE, WEI-BOR TSAI: "Surface Modification with Poly(sulfobetaine methacrylate- co -acrylic acid) To Reduce Fibrinogen Adsorption, Platelet Adhesion, and Plasma Coagulation", BIOMACROMOLECULES, AMERICAN CHEMICAL SOCIETY, US, vol. 12, no. 12, 12 December 2011 (2011-12-12), US , pages 4348 - 4356, XP055315720, ISSN: 1525-7797, DOI: 10.1021/bm2013185
Attorney, Agent or Firm:
CHENGDU ZHENGHUA PATENT AGENCY (CN)
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