Title:
ARTIFICIAL BLOOD VESSEL AND PREPARATION METHOD THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/138701
Kind Code:
A1
Abstract:
An artificial blood vessel and a preparation method thereof, relating to the fields of organ manufacturing and biological materials. The artificial blood vessel comprises an outer skin layer, a fibroblast layer, a smooth muscle cell layer, an inner skin cell layer, and an inner cavity. Using a comprehensive technique of plasma spraying, electro-spraying, electro-spinning, inverted moulding and 3D printing to implement the 3D ordered arrangement of the inner skin layer, smooth muscle cell layer, fibroblast layer and outer skin layer, using anti-coagulation factors to enhance the anti-coagulant properties of the artificial blood vessel, using a method of controlled release of growth factors to implement the distribution of induced differentiation of stem cells, and culturing the artificial blood vessel by means of a pulse reactor, such that the structure and function thereof mimics that of natural animal blood vessels, providing an alternative to vascular grafts; the present artificial blood vessel and preparation method thereof also applies to other tubular tissues and organs, such as the oesophagus, trachea, fallopian tubes, bile ducts, urethra, and bladder.
Inventors:
LIU CHANG (CN)
Application Number:
PCT/CN2015/079792
Publication Date:
September 09, 2016
Filing Date:
May 26, 2015
Export Citation:
Assignee:
LIU CHANG (CN)
International Classes:
A61F2/06; A61L27/40; A61L27/50
Domestic Patent References:
| WO2005003317A2 | 2005-01-13 |
Foreign References:
| CN1718172A | 2006-01-11 | |||
| CN101584612A | 2009-11-25 | |||
| CN103230309A | 2013-08-07 | |||
| JP2003024351A | 2003-01-28 |
Attorney, Agent or Firm:
BEIJING GRANDER IP LAW FIRM (CN)
北京鸿元知识产权代理有限公司 (CN)
北京鸿元知识产权代理有限公司 (CN)
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