Title:
ARTIFICIAL KETOREDUCTASE VARIANTS AND DESIGN METHODOLOGY THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/233233
Kind Code:
A1
Abstract:
Ketoreductase variants having activity on both (R) - (-) -1, 3-butanediol and (S) - (+) -1, 3-butanediol, and the computational methodology for designing the above mentioned ketoreductase variants. The ketoreductase variants disclosed in the present application can catalyze the reaction of synthesizing 4-hydroxy-2-butanone from racemic 1, 3-butanediol, which has industrial application prospects.
Inventors:
SHI SHUMIN (CN)
XU JUNPENG (CN)
BOCOLA MARCO (CN)
CAI BAOQIN (CN)
CHEN HAIBIN (CN)
YU MENGYING (CN)
LUO XIAO (CN)
LIANG YAFANG (CN)
HE KUIFANG (CN)
PENG QINLI (CN)
XU JUNPENG (CN)
BOCOLA MARCO (CN)
CAI BAOQIN (CN)
CHEN HAIBIN (CN)
YU MENGYING (CN)
LUO XIAO (CN)
LIANG YAFANG (CN)
HE KUIFANG (CN)
PENG QINLI (CN)
Application Number:
PCT/CN2022/087783
Publication Date:
November 10, 2022
Filing Date:
April 20, 2022
Export Citation:
Assignee:
ENZYMASTER NINGBO BIO ENG CO LTD (CN)
International Classes:
G16B20/50; C12P7/26
Domestic Patent References:
| WO2018101518A1 | 2018-06-07 |
Foreign References:
| US7438904B1 | 2008-10-21 | |||
| CN109086568A | 2018-12-25 | |||
| CN110938608A | 2020-03-31 | |||
| CN108048417A | 2018-05-18 | |||
| CN111321129A | 2020-06-23 | |||
| CN103087145A | 2013-05-08 |
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