Title:
ARTIFICIAL NUCLEIC ACID FOR INDUCING SPECIFIC THREE-DIMENSIONAL STRUCTURE
Document Type and Number:
WIPO Patent Application WO/2023/013613
Kind Code:
A1
Abstract:
The present invention addressing the problem of providing: a method for forming a three-dimensional structure dynamically by utilizing non-complementary base pairs in an oligonucleotide therapeutic; a modification mode for a nucleic acid maintaining a three-dimensional structure; and an artificial nucleic acid capable of bonding to a target sequence stably regardless of mutation. Provided are: an artificial nucleic acid for inducing a specific three-dimensional structure by hybridizing to a nucleic acid of interest that does not form a functional three-dimensional structure; a gene expression inhibitor and a nucleic acid detector including the same as an active ingredient; and a method for producing an artificial nucleic acid.
Inventors:
KONDO JIRO (JP)
Application Number:
PCT/JP2022/029566
Publication Date:
February 09, 2023
Filing Date:
August 01, 2022
Export Citation:
Assignee:
SOPHIA SCHOOL CORP (JP)
International Classes:
C12N15/113; A61K31/7088; A61K31/712; A61K31/713; A61K48/00; A61P43/00; C12N15/10; C12Q1/6813
Foreign References:
| JP2021126578A | 2021-09-02 |
Other References:
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BOONE E., SCHUSTER GARY B: "Long-range oxidative damage in duplex DNA: the effect of bulged G in a G-C tract and tandem G/A mispairs", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, vol. 30, no. 3, 1 February 2002 (2002-02-01), pages 830 - 837, XP093033676, DOI: 10.1093/nar/30.3.830
SCHROEDER KERSTEN T., DALDROP PETER, MCPHEE SCOTT A., LILLEY DAVID M.J.: "Structure and folding of a rare, natural kink turn in RNA with an A•A pair at the 2b•2n position", RNA, COLD SPRING HARBOR LABORATORY PRESS, US, vol. 18, no. 6, 1 June 2012 (2012-06-01), US , pages 1257 - 1266, XP093033681, ISSN: 1355-8382, DOI: 10.1261/rna.032409.112
WIMBERLY BRIAN, VARANI GABRIELE, TINOCO IGNACIO: "The Conformation of Loop E of Eukaryotic 5S Ribosomal RNA", BIOCHEMISTRY, vol. 32, 1 January 1993 (1993-01-01), pages 1078 - 1087, XP093033682
YANG, MEI (MONICA ET AL.: "Comparative Stability Determination of Oligonucleotide Duplexes in Gas and Solution Phas e", J. AM. SOC. MASS SPECTROM, vol. 15, 2004, pages 1354 - 1359, XP004548380, DOI: 10.1016/j.jasms.2004.06.008
LEONTIS, N.B. ET AL., NUCLEIC ACIDS RES., vol. 30, no. 16, 15 August 2002 (2002-08-15), pages 3497 - 3531
CORRELL, C. C. ET AL., NUCLEIC ACIDS RESEARCH, vol. 31, no. 23, 2003, pages 6806 - 6818
CORRELL, C. C. ET AL., PROC. NATL. ACAD. SCI., vol. 95, 1998, pages 13436 - 13441
GLUCK, A.WOOL, I. G., J. MOL. BIOL., vol. 256, 1996, pages 838 - 848
HUANG, L.LILLEY, D. M., JOURNAL OF MOLECULAR BIOLOGY, vol. 428, 2016, pages 790 - 801
HUANG, L.LILLEY, D. M., QUARTERLY REVIEWS OF BIOPHYSICS, vol. 51, no. e5, 2018
STROBEL, S. A. ET AL., RNA, vol. 10, no. 12, 2004, pages 1852 - 1854
CORRELL, C. C. ET AL., CELL, vol. 91, no. 5, 1997, pages 705 - 712
LEONTIS, N. B.WESTHOF, E, RNA, vol. 4, no. 9, 1998, pages 1134 - 1153
KLEIN, D. J. ET AL., JOURNAL OF MOLECULAR BIOLOGY, vol. 340, no. 1, 2004, pages 141 - 177
LESCOUTE, A. ET AL., NUCLEIC ACIDS RESEARCH, vol. 33, no. 8, 2005, pages 2395 - 2409
JANG, S. B. ET AL., ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY, vol. 60, no. 5, 2004, pages 829 - 835
ALTSCHUL, S. F. ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
MCPHEE, S. A. ET AL., NATURE COMMUNICATIONS, vol. 5, no. 1, 2014, pages 1 - 6
COONROD, L. A. ET AL., BIOCHEMISTRY, vol. 51, no. 42, 2012, pages 8330 - 8337
Y L CHIU AND T M RANA: "RNAi in human cells: Basic structural and functional features of small interfering RNA", MOLECULAR CELL, ELSEVIER, vol. 10, no. 3, 1 September 2002 (2002-09-01), AMSTERDAM, NL, pages 549 - 561, XP002978510, ISSN: 1097-2765, DOI: 10.1016/S1097-2765(02)00652-4
BOONE E., SCHUSTER GARY B: "Long-range oxidative damage in duplex DNA: the effect of bulged G in a G-C tract and tandem G/A mispairs", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, vol. 30, no. 3, 1 February 2002 (2002-02-01), pages 830 - 837, XP093033676, DOI: 10.1093/nar/30.3.830
SCHROEDER KERSTEN T., DALDROP PETER, MCPHEE SCOTT A., LILLEY DAVID M.J.: "Structure and folding of a rare, natural kink turn in RNA with an A•A pair at the 2b•2n position", RNA, COLD SPRING HARBOR LABORATORY PRESS, US, vol. 18, no. 6, 1 June 2012 (2012-06-01), US , pages 1257 - 1266, XP093033681, ISSN: 1355-8382, DOI: 10.1261/rna.032409.112
WIMBERLY BRIAN, VARANI GABRIELE, TINOCO IGNACIO: "The Conformation of Loop E of Eukaryotic 5S Ribosomal RNA", BIOCHEMISTRY, vol. 32, 1 January 1993 (1993-01-01), pages 1078 - 1087, XP093033682
YANG, MEI (MONICA ET AL.: "Comparative Stability Determination of Oligonucleotide Duplexes in Gas and Solution Phas e", J. AM. SOC. MASS SPECTROM, vol. 15, 2004, pages 1354 - 1359, XP004548380, DOI: 10.1016/j.jasms.2004.06.008
LEONTIS, N.B. ET AL., NUCLEIC ACIDS RES., vol. 30, no. 16, 15 August 2002 (2002-08-15), pages 3497 - 3531
CORRELL, C. C. ET AL., NUCLEIC ACIDS RESEARCH, vol. 31, no. 23, 2003, pages 6806 - 6818
CORRELL, C. C. ET AL., PROC. NATL. ACAD. SCI., vol. 95, 1998, pages 13436 - 13441
GLUCK, A.WOOL, I. G., J. MOL. BIOL., vol. 256, 1996, pages 838 - 848
HUANG, L.LILLEY, D. M., JOURNAL OF MOLECULAR BIOLOGY, vol. 428, 2016, pages 790 - 801
HUANG, L.LILLEY, D. M., QUARTERLY REVIEWS OF BIOPHYSICS, vol. 51, no. e5, 2018
STROBEL, S. A. ET AL., RNA, vol. 10, no. 12, 2004, pages 1852 - 1854
CORRELL, C. C. ET AL., CELL, vol. 91, no. 5, 1997, pages 705 - 712
LEONTIS, N. B.WESTHOF, E, RNA, vol. 4, no. 9, 1998, pages 1134 - 1153
KLEIN, D. J. ET AL., JOURNAL OF MOLECULAR BIOLOGY, vol. 340, no. 1, 2004, pages 141 - 177
LESCOUTE, A. ET AL., NUCLEIC ACIDS RESEARCH, vol. 33, no. 8, 2005, pages 2395 - 2409
JANG, S. B. ET AL., ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY, vol. 60, no. 5, 2004, pages 829 - 835
ALTSCHUL, S. F. ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
MCPHEE, S. A. ET AL., NATURE COMMUNICATIONS, vol. 5, no. 1, 2014, pages 1 - 6
COONROD, L. A. ET AL., BIOCHEMISTRY, vol. 51, no. 42, 2012, pages 8330 - 8337
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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