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Title:
ARTIFICIAL NUCLEOSIDE, ARTIFICIAL NUCLEOTIDE, AND ARTIFICIAL OLIGONUCLEOTIDE
Document Type and Number:
WIPO Patent Application WO/2017/018360
Kind Code:
A1
Abstract:
Provided is an artificial nucleoside, or artificial nucleotide, that is a compound represented by formula (I) or a salt thereof. In formula (I), Bx is a pyrimidine base, thioxopyrimidine base, or purine base, R1, R2, R3 and R4 are hydrogen atoms, C1-6 alkyl groups, and the like, and Z1 and Z2 are hydrogen atoms, hydroxyl-group protecting groups, phosphorus-containing groups, and the like.

Inventors:
IRIYAMA, Yusuke (Ltd. Chemical Research Laboratories 10-1, Tsuboi-Nishi 2-chome, Funabashi-sh, Chiba 07, 〒2748507, JP)
Application Number:
JP2016/071637
Publication Date:
February 02, 2017
Filing Date:
July 22, 2016
Export Citation:
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Assignee:
NISSAN CHEMICAL INDUSTRIES, LTD. (7-1 Kanda-Nishikicho 3-chome, Chiyoda-ku Tokyo, 54, 〒1010054, JP)
International Classes:
C07H19/067; C07H19/167; C07H21/02; A61K31/7068; A61K31/7072; A61K31/7076; A61K31/708; A61K31/712; A61K48/00; C12N15/09
Domestic Patent References:
WO2011085102A12011-07-14
WO2014112463A12014-07-24
WO2011156202A12011-12-15
WO2011052436A12011-05-05
WO1998039352A11998-09-11
Other References:
KUMAR RAVINDRA ET AL.: "The first analogues of LNA (locked nucleic acids): Phosphorothioate- LNA and 2'-thio-LNA", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 8, 1998, pages 22 19 - 2222, XP004137249, ISSN: 0960-894X
Attorney, Agent or Firm:
TSUKUNI & ASSOCIATES et al. (Kojimachi Business Center, 5-3-1 Kojimachi, Chiyoda-k, Tokyo 83, 〒1020083, JP)
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