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Title:
ARTIFICIAL NUCLEOSIDE AND ARTIFICIAL NUCLEOTIDE, AND ARTIFICIAL OLIGONUCLEOTIDE
Document Type and Number:
WIPO Patent Application WO/2017/142054
Kind Code:
A1
Abstract:
Provided is an artificial nucleoside or an artificial nucleotide which can constitute an artificial oligonucleotide having excellent nuclease resistance. An artificial nucleoside or an artificial nucleotide, which is a compound represented by formula (I) and a salt thereof. (Bx represents a pyrimidine base or a purine base; R1, R2, R3 and R4 independently represent a hydrogen atom, a C1-6 alkyl group or the like; Y represents NR5R6 (wherein R5 and R6 independently represent a hydrogen atom, a C1-6 alkyl group or the like, or R5 and R6, in conjunction with a nitrogen atom to which R5 and R6 are bound, together form a 3- to 11-membered nitrogenated non-aromatic heterocyclic ring), or a C2-9 aromatic heterocyclic group which may be substituted); Z1 and Z2 independently represent a hydrogen atom, a protecting group for a hydroxy group, a phosphorus-containing group or the like; and n represents an integer of 1 to 3.)

Inventors:
SEIO Kohji (2-12-1 Ookayama, Meguro-k, Tokyo 50, 〒1528550, JP)
MASAKI Yoshiaki (2-12-1 Ookayama, Meguro-k, Tokyo 50, 〒1528550, JP)
YAMAMOTO Keishi (2-12-1 Ookayama, Meguro-k, Tokyo 50, 〒1528550, JP)
YOSHIDA Keita (2-12-1 Ookayama, Meguro-k, Tokyo 50, 〒1528550, JP)
IRIYAMA Yusuke (Ltd. Chemical Research Laboratories 10-1, Tsuboi-Nishi 2-chome, Funabashi-sh, Chiba 07, 〒2748507, JP)
NAKAJIMA Hiroyuki (Ltd. Biological Research Laboratories 1470, Shiraoka, Shiraoka-sh, Saitama 94, 〒3490294, JP)
KANAKI Tatsuro (Ltd. Biological Research Laboratories 1470, Shiraoka, Shiraoka-sh, Saitama 94, 〒3490294, JP)
Application Number:
JP2017/005835
Publication Date:
August 24, 2017
Filing Date:
February 17, 2017
Export Citation:
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Assignee:
TOKYO INSTITUTE OF TECHNOLOGY (2-12-1, Ookayama Meguro-k, Tokyo 50, 〒1528550, JP)
NISSAN CHEMICAL INDUSTRIES, LTD. (7-1 Kanda-Nishikicho 3-chome, Chiyoda-ku Tokyo, 54, 〒1010054, JP)
International Classes:
C07H19/067; A61P3/06; A61P21/04; C07H21/02; A61K31/7115; A61K48/00
Domestic Patent References:
WO2014131892A12014-09-04
WO2005021570A12005-03-10
WO2007143315A22007-12-13
WO2008043753A22008-04-17
WO2008029619A12008-03-13
WO2008049085A12008-04-24
WO2011052436A12011-05-05
Foreign References:
JPH05504552A1993-07-15
JP2012506701A2012-03-22
JPH072889A1995-01-06
JP5194256B22013-05-08
JPH10304889A1998-11-17
JPH10195098A1998-07-28
JP2002521310A2002-07-16
Other References:
MILTON,S. ET AL.: "Synthesis and Stability of a 2 '-O-[N-(Aminoethyl)carbamoyl]methyladenosine- Containing Dinucleotide", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2013, no. 31, 2013, pages 7184 - 7192, XP055110607
HWANG,J. ET AL.: "Transcription inhibition using modified pentanucleotides", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 11, no. 10, 2003, pages 2321 - 2328, XP055540351
OZAKI, H. ET AL.: "Synthesis and properties of oligodeoxyribonucleotides bearing a polyamino group at the 2' position via 2'-O- carbamoylmethyl and 2'-S-carbamoylmethyl groups", NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS, vol. 28, no. 10, 2009, pages 943 - 952, XP002722433
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Attorney, Agent or Firm:
TSUKUNI & ASSOCIATES et al. (Kojimachi Business Center, 5-3-1 Kojimachi, Chiyoda-k, Tokyo 83, 〒1020083, JP)
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