Title:
ARTIFICIAL PEPTIDE CAPABLE OF DEGRADING AMYLOIDS AND UTILIZATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/060333
Kind Code:
A1
Abstract:
Provided is a peptide characterized by having a structure, wherein a peptide that comprises an amino acid sequence represented by formula (I) is attached to the C-terminal side of a peptide that forms an α-helix, or a salt thereof:
(I) HX1X2SDX3X4 (SEQ ID NO:1)
[wherein X1 and X2 may be the same or different and represent an arbitrary amino acid residue; and X3 and X4 may be the same or different and represent a hydrophobic amino acid].
The artificial peptide is capable of degrading amyloids. By using this artificial peptide, therefore, an agent for degrading amyloids, an agent for detecting amyloids, a method for degrading amyloids whereby amyloids can be degraded under physiological conditions, a simple method for detecting amyloids, a medicinal composition for treating amyloid-associated diseases and a composition for diagnosing amyloid associated-diseases can be provided.
Inventors:
TAMURA ATSUO (JP)
IIDA YOSHIHIRO (JP)
IIDA YOSHIHIRO (JP)
Application Number:
PCT/JP2014/078053
Publication Date:
April 30, 2015
Filing Date:
October 22, 2014
Export Citation:
Assignee:
NAT UNIV CORP UNIV KOBE (JP)
International Classes:
C07K19/00; A61K38/00; A61P25/28; A61P43/00; C07K7/06; C07K14/00; G01N33/53; G01N33/566
Foreign References:
| JP2000509246A | 2000-07-25 | |||
| JP2003274968A | 2003-09-30 | |||
| JP2002525024A | 2002-08-13 | |||
| JP2007535494A | 2007-12-06 | |||
| JP2011513440A | 2011-04-28 | |||
| JP2010120942A | 2010-06-03 |
Other References:
DATABASE GENBANK 4 February 2013 (2013-02-04), BECKER EA . ET AL., retrieved from http://www.ncbi.nlm.nih.gov/protein/ ELZ91527 accession no. LZ91527
BRANDENBURG, E. ET AL.: "Inhibition of amyloid aggregation by formation of helical assemblies", CHEM. EUR. J., vol. 17, no. 38, 2011, pages 10651 - 10661
VIET, MH. ET AL.: "Inhibition of aggregation of amyloid peptides by beta-sheet breaker peptides and their binding affinity", J. PHYS. CHEM. B, vol. 115, no. 22, 2011, pages 7433 - 7446
BRANDENBURG, E. ET AL.: "Inhibition of amyloid aggregation by formation of helical assemblies", CHEM. EUR. J., vol. 17, no. 38, 2011, pages 10651 - 10661
VIET, MH. ET AL.: "Inhibition of aggregation of amyloid peptides by beta-sheet breaker peptides and their binding affinity", J. PHYS. CHEM. B, vol. 115, no. 22, 2011, pages 7433 - 7446
Attorney, Agent or Firm:
IWATANI, Ryo (JP)
Tatsu Iwatani (JP)
Tatsu Iwatani (JP)
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