Title:
ARTIFICIAL RED BLOOD CELL HAVING ABILITY TO INHIBIT TRANSFORMATION OF HEMOGLOBIN INTO METHEMOGLOBIN
Document Type and Number:
WIPO Patent Application WO/2017/150637
Kind Code:
A1
Abstract:
The present invention inhibits, in an artificial red blood cell containing purified and enriched hemoglobin that substantially has no enzymatic activity to reduce methemoglobin, transformation of the hemoglobin into methemoglobin. Provided is an artificial red blood cell which comprises: an aqueous solution that contains NADH and/or NADPH and hemoglobin; and a capsule that includes the aqueous solution, wherein the aqueous solution and the capsule substantially have no enzymatic activity to reduce methemoglobin.
Inventors:
SAKAI HIROMI (JP)
YAMADA MAGOHEI (JP)
YAMADA MAGOHEI (JP)
Application Number:
PCT/JP2017/008187
Publication Date:
September 08, 2017
Filing Date:
March 01, 2017
Export Citation:
Assignee:
PUBLIC UNIV CORP NARA MEDICAL UNIV (JP)
International Classes:
A61K38/16; A61K9/127; A61K47/16; A61K47/24; A61K47/28; A61K47/34; A61P7/08
Foreign References:
| JP2002161047A | 2002-06-04 | |||
| JPH06321802A | 1994-11-22 | |||
| JPH0459735A | 1992-02-26 | |||
| JPH02178233A | 1990-07-11 |
Other References:
SAKAI, H. ET AL.: "Red Blood Cells Donate Electrons to Methylene Blue Mediated Chemical Reduction of Methemoglobin Compartmentalized in Liposome in Blood", BIOCONJUG CHEM, vol. 25, no. 7, 2014, pages 1301 - 10, XP055414986, ISSN: 1043-1802
HIROMI SAKAI ET AL.: "Sekkekkyu Kaitokei ga Sansei suru Denshi Energy no Katsuyo ni yoru Jinko Sekkekkyu (Hemoglobin Vesicle) no Kino Jizoku Koka", DAI 95 ANNUAL MEETING OF THE CHEMICAL SOCIETY OF JAPAN, 2015, Koen Yokoshu III, pages 820
MAGOHEI YAMADA ET AL.: "Hemoglobin no Met-ka o Yokusei suru Kino o Yusuru Jinko Sekkekkyu", ARTIFICIAL BLOOD, vol. 24, no. 1, 31 October 2016 (2016-10-31), pages 36, ISSN: 1341-1594
HIROMI SAKAI ET AL.: "Sekkekkyu Kaitokei ga Sansei suru Denshi Energy no Katsuyo ni yoru Jinko Sekkekkyu (Hemoglobin Vesicle) no Kino Jizoku Koka", DAI 95 ANNUAL MEETING OF THE CHEMICAL SOCIETY OF JAPAN, 2015, Koen Yokoshu III, pages 820
MAGOHEI YAMADA ET AL.: "Hemoglobin no Met-ka o Yokusei suru Kino o Yusuru Jinko Sekkekkyu", ARTIFICIAL BLOOD, vol. 24, no. 1, 31 October 2016 (2016-10-31), pages 36, ISSN: 1341-1594
Attorney, Agent or Firm:
TSUKUNI & ASSOCIATES et al. (JP)
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