Title:
ARTIFICIAL SKIN TISSUE, ARTIFICIAL SKIN MODEL AND MANUFACTURING METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2014/038599
Kind Code:
A1
Abstract:
A novel method is provided which is able to manufacture an artificial skin model including dendric cells. In the method for manufacturing the artificial skin model, coated cells are cultured whose cell surface is coated with a coating containing an extracellular matrix component, a dermal tissue layer is formed on which these coated cells are layered, type IV collagen is brought into contact with the dermal tissue layer to form a basal layer containing type IV collagen on the dermal tissue layer, and epidermal cells are arranged on the basal layer to form an epidermal layer. At the very least either the dermal tissue layer or the epidermal layer contains dendric cells.
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Inventors:
AKASHI MITSURU (JP)
MATSUSAKI MICHIYA (JP)
NAWANO MASAAKI (JP)
HASHIMOTO KOJI (JP)
SHIRAKATA YUJI (JP)
MATSUSAKI MICHIYA (JP)
NAWANO MASAAKI (JP)
HASHIMOTO KOJI (JP)
SHIRAKATA YUJI (JP)
Application Number:
PCT/JP2013/073833
Publication Date:
March 13, 2014
Filing Date:
September 04, 2013
Export Citation:
Assignee:
UNIV OSAKA (JP)
BIOMEDICAL TECHNOLOGY HYBRID CO LTD (JP)
NAT UNIV CORP EHIME UNIV (JP)
BIOMEDICAL TECHNOLOGY HYBRID CO LTD (JP)
NAT UNIV CORP EHIME UNIV (JP)
International Classes:
C12N5/0784; A61L27/00; C12N1/00; C12N5/07
Domestic Patent References:
| WO2012133629A1 | 2012-10-04 | |||
| WO2005087286A1 | 2005-09-22 |
Foreign References:
| JP2004166685A | 2004-06-17 | |||
| JP2011004935A | 2011-01-13 | |||
| JP2773058B2 | 1998-07-09 | |||
| JP2012115254A | 2012-06-21 | |||
| JP2010172247A | 2010-08-12 | |||
| JP2012205516A | 2012-10-25 | |||
| JP2012115254A | 2012-06-21 | |||
| JP2773058B2 | 1998-07-09 | |||
| JP2005269923A | 2005-10-06 |
Other References:
MICHIYA MATSUSAKI ET AL.: "Kekkan Oyobi Limph-kan'yo Network o Yusuru Hifu Model no Kochiku", REGENERATIVE MEDICINE, vol. 11, no. SUPL 2, 16 May 2012 (2012-05-16), pages 164, XP008178572
TADASHI UCHINO ET AL.: "Construction of Three-dimensional Human Skin Model Involving Dendritic Cells and Its Application to Skin Sensitization Test", JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, vol. 128, no. 1, 2008, pages 45 - 50, XP055235018
LAMMERS,G. ET AL.: "A molecularly defined array based on native fibrillar collagen for the assessment of skin tissue engineering biomaterials", BIOMATERIALS, vol. 30, 2009, pages 6213 - 6220, XP026574959
See also references of EP 2894219A4
TADASHI UCHINO ET AL.: "Construction of Three-dimensional Human Skin Model Involving Dendritic Cells and Its Application to Skin Sensitization Test", JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, vol. 128, no. 1, 2008, pages 45 - 50, XP055235018
LAMMERS,G. ET AL.: "A molecularly defined array based on native fibrillar collagen for the assessment of skin tissue engineering biomaterials", BIOMATERIALS, vol. 30, 2009, pages 6213 - 6220, XP026574959
See also references of EP 2894219A4
Attorney, Agent or Firm:
IKEUCHI SATO & PARTNER PATENT ATTORNEYS (JP)
Patent business corporation Ikeuchi and Sato and partners (JP)
Patent business corporation Ikeuchi and Sato and partners (JP)
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