ARYL CARBAMATE OLIGOMERS FOR HYDROLYZABLE PRODRUGS AND PRODRUGS COMPRISING SAME

Title:

ARYL CARBAMATE OLIGOMERS FOR HYDROLYZABLE PRODRUGS AND PRODRUGS COMPRISING SAME

Document Type and Number:

WIPO Patent Application WO2005016240

Kind Code:

A3

Abstract:

The present invention provides a compound having a formula: (I) where R¹ is selected from the group consisting of alkyl, -CH₂(OC₂H4)OCH₃, and -(OC₂H₄)OCH₃; n is 0-4; Olig is an oligomer having a formula (I) where L is a optional linker moiety selected from the group consisting of CH₂O , CH₂OX , OX , C(O) , C(O)X, NH , NHC(O) , XNHC(O) , NHC(O)X , C(O)NH , C(O)NHX , and (I), where X is alkyl_1-6 or is not present, Y is N or O or is not present, and R³ is alkyl_1-6; PAG is a linear or branched polyalkylene glycol moiety; R² is an alkyl_1-22 capping moiety if X is present or alkyl_2-22 if X is not present; and q is a number from 1 to the maximum number of branches on PAG; and m is 1-5.

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Inventors:

EKWURIBE NNOCHIRI N (US)
ODENBAUGH AMY L (US)

Application Number:

PCT/US2004/015004

Publication Date:

September 28, 2006

Filing Date:

May 06, 2004

Export Citation:

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Assignee:

NOBEX CORP (US)
EKWURIBE NNOCHIRI N (US)
ODENBAUGH AMY L (US)

International Classes:

C07C43/20; C07C43/23; C07C45/67; C07C45/71; C07C47/575; C07C49/84; C07C235/48; C07C259/00; C07C271/00; C07C271/22; C07C271/28; A61K

Foreign References:

US6413507B1

2002-07-02

Other References: