Title:
ARYL DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2008/126731
Kind Code:
A1
Abstract:
The invention relates to novel aryl derivatives which have excellent blood sugar
lowering effect and are effective in treating diseases of glycometabolism and
lipid metabolism, or diseases in which peroxisome proliferator activated receptor
(PPAR) γ participates and/or in preventing the onset of these diseases;
or pharmacologically acceptable salts thereof. Aryl derivatives represented
by the general formula (I) or pharmacologically acceptable salts thereof: [Chemical
formula 1] E - A - Y (I) (II) (III) (IV) wherein E is a group represented by the general
formula: -CH2NHCOR1, a group represented by the general
formula: -CH(CH3)NHCOR1 (wherein R1 is C6-10
aryl which may be substituted with one to five groups independently selected
from substituent group (a), or the like), or the like; A is a group represented
by the general formula (II), a group represented by the general formula (III),
or a group represented by the general formula (IV) (wherein R2 is hydrogen,
halogeno, or the like; R3 is hydrogen, halogeno, or the like; R4
is C1-6 alkyl; V is =CH- or the like; Z is =CH- or the like; Q is =CH- or the
like; CE and CY are each a single bond; CE is attached
to a group represented by symbol “E”; and CY is attached
to a group represented by symbol “Y”); and Y is a group represented
by the general formula: -NHSO2R5, a group represented by
the general formula: -CH2OR5 (wherein R5 is C1-6
alkyl, C6-10 aryl which may be substituted with one to five groups independently
selected from substituent group (a), or the like), or the like, with substituent
group (a) consisting of halogeno, C1-6 alkyl, C1-6 hydroxyalkyl,
and so on.
Inventors:
MORI MAKOTO
MOMOSE TAKAYUKI
YOSHIDA JURI
ONISHI YOSHIYUKI
MOMOSE TAKAYUKI
YOSHIDA JURI
ONISHI YOSHIYUKI
Application Number:
PCT/JP2008/056540
Publication Date:
October 23, 2008
Filing Date:
April 02, 2008
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
MORI MAKOTO
MOMOSE TAKAYUKI
YOSHIDA JURI
ONISHI YOSHIYUKI
MORI MAKOTO
MOMOSE TAKAYUKI
YOSHIDA JURI
ONISHI YOSHIYUKI
International Classes:
C07C235/46; A61K31/18; A61K31/381; A61K31/426; A61K31/455; A61K31/5375; A61P3/10; C07C235/52; C07C311/21; C07D213/82; C07D277/20; C07D277/56; C07D295/14; C07D333/38; C07D417/12
Domestic Patent References:
| WO2003070691A1 | 2003-08-28 |
Attorney, Agent or Firm:
ISHIBASHI, Koki et al. (LIMITED1-16-13, Kitakasa, Edogawa-ku Tokyo 81, JP)
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