ARYL AND HETEROARYL COMPOUNDS AND METHODS TO MODULATE COAGULATION

Title:

ARYL AND HETEROARYL COMPOUNDS AND METHODS TO MODULATE COAGULATION

Document Type and Number:

WIPO Patent Application WO2004014844

Kind Code:

A3

Abstract:

This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as antagonists, or more preferably, partial antagonist of factor IX and thus, may be used to inhibit the intrinsic pathway of blood coagulation. The compounds are useful in a variety of applications including the management, treatment and/or control of diseases caused in part by the intrinsic clotting pathway utilizing factor IX. Such diseases or disease states include stroke, myocardial infarction, aneurysm surgery, and deep vein thrombosis associated with surgical procedures, long periods of confinement, and acquired or inherited pro-coagulant states.

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Inventors:

MJALLI ADNAN M M (US)
ANDREWS ROB (US)
GUO XIAO-CHUAN (US)
CHRISTEN DANIEL PETER (US)
GOHIMMUKKULA DEVI REDDY (US)
HUANG GUOXIANG (US)
ROTHLEIN ROBERT (US)
TYAGI SAMEER (US)
YARAMASU TRIPURA (US)
BEHME CHRISTOPHER (US)

Application Number:

PCT/US2003/025045

Publication Date:

April 28, 2005

Filing Date:

August 08, 2003

Export Citation:

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Assignee:

TRANSTECH PHARMA INC (US)
MJALLI ADNAN M M (US)
ANDREWS ROB (US)
GUO XIAO-CHUAN (US)
CHRISTEN DANIEL PETER (US)
GOHIMMUKKULA DEVI REDDY (US)
HUANG GUOXIANG (US)
ROTHLEIN ROBERT (US)
TYAGI SAMEER (US)
YARAMASU TRIPURA (US)
BEHME CHRISTOPHER (US)

International Classes:

A61K31/166; A61K31/167; A61K31/198; A61K31/341; A61K31/343; A61K31/381; A61K31/402; A61K31/4025; A61K31/4155; A61K31/4164; A61K31/421; A61K31/422; A61K31/4245; A61K31/433; A61K31/44; A61K31/4409; A61K31/4418; A61K31/4453; A61K31/4465; A61K31/472; A61K31/501; A61K31/506; A61K31/517; A61K31/5377; A61K31/55; A61K31/609; A61K31/625; A61K31/63; A61P7/02; A61P9/06; A61P9/10; A61P9/14; A61P13/12; A61P15/06; A61P29/00; A61P37/00; A61P41/00; A61P43/00; C07C233/29; C07C233/87; C07C235/42; C07C235/52; C07C235/60; C07C235/66; C07C237/20; C07C237/36; C07C237/42; C07C237/44; C07C255/58; C07C255/60; C07C257/18; C07C271/20; C07C271/44; C07C311/18; C07C311/19; C07C311/29; C07C311/44; C07C317/14; C07C317/28; C07C317/36; C07C317/46; C07C323/36; C07D207/09; C07D207/267; C07D207/27; C07D207/48; C07D211/14; C07D211/26; C07D213/30; C07D213/38; C07D213/55; C07D213/56; C07D213/70; C07D213/71; C07D213/74; C07D213/75; C07D213/81; C07D213/82; C07D215/36; C07D217/02; C07D217/04; C07D217/16; C07D217/22; C07D217/26; C07D231/12; C07D231/14; C07D231/18; C07D233/84; C07D239/94; C07D249/08; C07D261/10; C07D263/32; C07D271/10; C07D277/20; C07D277/44; C07D277/46; C07D277/54; C07D285/06; C07D285/08; C07D295/08; C07D295/092; C07D295/14; C07D295/155; C07D307/52; C07D307/66; C07D307/79; C07D307/85; C07D317/60; C07D317/66; C07D333/20; C07D333/24; C07D333/38; C07D333/70; C07D401/04; C07D403/04; C07D409/04; C07D409/06; C07D413/04; C07D207/26; (IPC1-7): C07C233/29; C07C233/87; C07C235/42; C07C235/52; C07C235/60; C07C235/66; C07D217/16; C07D217/22; A61K31/33; A61K31/198; A61P7/02

Domestic Patent References:

WO2002018320A2	2002-03-07
WO1999036393A1	1999-07-22
WO1999026923A1	1999-06-03
WO2001021584A1	2001-03-29
WO1995012611A1	1995-05-11

Foreign References:

GB2354440A	2001-03-28
GB1501541A	1978-02-15

Other References:

H.S. KNOWLES ET AL, TETRAHEDRON, vol. 57, no. 38, 2001, pages 8115 - 8124, XP004319720
M.J. O'DONNELL ET AL, TETRAHEDRON, vol. 55, no. 20, 1999, pages 6347 - 6362, XP004165578
G.M. CASTANEDO ET AL, BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 12, no. 20, 2002, pages 2913 - 2917, XP002250476
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002319820, retrieved from STN Database accession no. 1973:504834
P.D. GREENSPAN ET AL, BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 7, no. 7, 1997, pages 949 - 954, XP004136162

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