Title:
ARYL OR HETEROARYL DERIVATIVE, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT FOR TREATMENT OF KINASE-RELATED DISEASE
Document Type and Number:
WIPO Patent Application WO/2020/149553
Kind Code:
A1
Abstract:
The present invention relates to an aryl or heteroaryl derivative and a pharmaceutical composition comprising same as an active ingredient for treatment of kinase-related disease. An aryl or heteroaryl derivative provided according to an aspect of the present invention exhibits an excellent inhibitory activity against receptor-interacting serine/threonine-protein kinase 1 (RIPK1) and as such, can be used as a therapeutic agent for RIPK1-related disease.
Inventors:
LI HUA (KR)
JO SEO HYUN (KR)
RYU HEESUN (KR)
KIM SEUNGSU (KR)
CHOI HYEONJIN (KR)
DO WOOMI (KR)
KIM HYUNKYUNG (KR)
CHOI JIEUN (KR)
KIM DAEKWON (KR)
SON JUNG BEOM (KR)
KIM NAM DOO (KR)
JO SEO HYUN (KR)
RYU HEESUN (KR)
KIM SEUNGSU (KR)
CHOI HYEONJIN (KR)
DO WOOMI (KR)
KIM HYUNKYUNG (KR)
CHOI JIEUN (KR)
KIM DAEKWON (KR)
SON JUNG BEOM (KR)
KIM NAM DOO (KR)
Application Number:
PCT/KR2019/018834
Publication Date:
July 23, 2020
Filing Date:
December 31, 2019
Export Citation:
Assignee:
VORONOI CO LTD (KR)
VORONOIBIO CO LTD (KR)
VORONOIBIO CO LTD (KR)
International Classes:
C07D487/04; A61K31/437; A61K31/4439; A61K31/5025; A61K31/519; C07D413/12; C07D471/04
Domestic Patent References:
| WO2008048589A2 | 2008-04-24 | |||
| WO1998029117A1 | 1998-07-09 |
Foreign References:
| US20180353480A1 | 2018-12-13 | |||
| US20170305920A1 | 2017-10-26 |
Other References:
HARRIS, P. A. ET AL.: "Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis. 2013", MED. CHEM. LETT., vol. 4, pages 1238 - 1243, XP055123759, DOI: 10.1021/ml400382p
Attorney, Agent or Firm:
DANA PATENT LAW FIRM (KR)
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