Title:
ARYL OR HETEROARYL FUSED IMIDAZOLE COMPOUNDS AS ANTI-INFLAMMATORY AND ANALGESIC AGENTS
Document Type and Number:
WIPO Patent Application WO2002032900
Kind Code:
A3
Abstract:
This invention provides a compound of the formula (I): or the pharmaceutically acceptable salts thereof, wherein Y<1>, Y<2>, Y<3>, and Y<4> are independently selected from N, CH, etc.; R<1> is H, C1-8 alkyl, etc.; Q<1> is a 5-12 membered monocyclic or bicyclic aromatic ring optionally containing up to 4 heteroatoms selected from O, N and S, etc.; A is a 5-6 membered monocyclic aromatic ring optionally containing up to 3 heteroatoms selected from O, N and S, etc.; B is C1-6 alkylene optionally substituted with an oxo group, etc.; W is NH, O, etc.; R<2> is H, C 1-4 alkyl, etc.; Z is a 5-12 membered monocyclic or bicyclic aromatic ring optionally containing up to 3 heteroatoms selected from O, N and S, etc.; L is halo, C1-4 alkyl, etc.; m is o,1 or 2; R<3> and R<4> are independently selected from H and C1-4 alkyl; R<5> is H, C1-4 alkyl, etc.; Q<2> is a 5-12 membered monocyclic or bicyclic aromatic ring or tricyclic ring optionally containing up to 3 heteroatoms selected from O, N and S, etc. These compounds are useful for the treatment of medical conditions mediated by prostaglamndin such as pain, fever or inflammation, etc. This invention also provides a pharmaceutical composition comprising the above compound.
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Inventors:
NAKAO KAZUNARI (JP)
OKUMURA YOSHIYUKI (JP)
MATSUMIZU MIYAKO (JP)
UNEO NAOMI (JP)
HASHIZUME YOSHINOBU (JP)
KATO TOMOKI (JP)
KAWAI AKIYOSHI (JP)
MIYAKE YORIKO (JP)
NUKUI SEIJI (JP)
SHINJYO KATSUHIRO (JP)
TANIGUCHI KANA (JP)
OKUMURA YOSHIYUKI (JP)
MATSUMIZU MIYAKO (JP)
UNEO NAOMI (JP)
HASHIZUME YOSHINOBU (JP)
KATO TOMOKI (JP)
KAWAI AKIYOSHI (JP)
MIYAKE YORIKO (JP)
NUKUI SEIJI (JP)
SHINJYO KATSUHIRO (JP)
TANIGUCHI KANA (JP)
Application Number:
PCT/IB2001/001940
Publication Date:
August 08, 2002
Filing Date:
October 15, 2001
Export Citation:
Assignee:
PFIZER PHARMA (JP)
NAKAO KAZUNARI (JP)
OKUMURA YOSHIYUKI (JP)
MATSUMIZU MIYAKO (JP)
UNEO NAOMI (JP)
HASHIZUME YOSHINOBU (JP)
KATO TOMOKI (JP)
KAWAI AKIYOSHI (JP)
MIYAKE YORIKO (JP)
PFIZER (US)
NUKUI SEIJI (JP)
SHINJYO KATSUHIRO (JP)
TANIGUCHI KANA (JP)
NAKAO KAZUNARI (JP)
OKUMURA YOSHIYUKI (JP)
MATSUMIZU MIYAKO (JP)
UNEO NAOMI (JP)
HASHIZUME YOSHINOBU (JP)
KATO TOMOKI (JP)
KAWAI AKIYOSHI (JP)
MIYAKE YORIKO (JP)
PFIZER (US)
NUKUI SEIJI (JP)
SHINJYO KATSUHIRO (JP)
TANIGUCHI KANA (JP)
International Classes:
G01N33/48; A61K31/00; A61K31/4178; A61K31/4184; A61K31/4188; A61K31/427; A61K31/437; A61K31/4439; A61K31/444; A61K31/454; A61K31/4725; A61K31/506; A61K31/52; A61K31/64; A61K45/00; A61P1/00; A61P1/02; A61P1/04; A61P3/10; A61P5/00; A61P7/02; A61P7/04; A61P7/08; A61P9/00; A61P9/10; A61P9/12; A61P9/14; A61P11/02; A61P11/06; A61P13/12; A61P15/04; A61P15/06; A61P17/00; A61P17/02; A61P17/16; A61P19/02; A61P19/06; A61P19/08; A61P19/10; A61P21/00; A61P25/00; A61P25/02; A61P25/04; A61P25/06; A61P25/20; A61P25/28; A61P27/00; A61P27/06; A61P29/00; A61P31/12; A61P31/16; A61P31/18; A61P35/00; A61P35/04; A61P37/00; A61P37/02; A61P37/06; A61P37/08; A61P41/00; A61P43/00; C07D235/06; C07D235/08; C07D235/12; C07D235/14; C07D235/16; C07D235/30; C07D401/04; C07D401/06; C07D401/12; C07D403/04; C07D403/06; C07D403/12; C07D413/12; C07D417/04; C07D417/12; C07D471/04; C07D473/00; C07D491/04; C07D491/048; C07D491/056; C07D521/00; G01N33/15; G01N33/50; C07D235/10; (IPC1-7): C07D471/04; A61K31/4178; A61K31/437; A61P29/00; C07D235/08; C07D491/04; C07D473/00; C07D521/00; C07D401/06; C07D401/04; C07D417/12; C07D403/12; C07D401/12; C07D235/30; C07D417/04; C07D403/04; C07D403/06
Domestic Patent References:
| WO1999047497A2 | 1999-09-23 |
Foreign References:
| EP0405391A1 | 1991-01-02 |
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