Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
ARYL HYDROCARBON RECEPTOR ANTAGONISTS AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO/2020/051207
Kind Code:
A3
Abstract:
The disclosure relates to aryl hydrocarbon receptor antagonists as well as methods of modulating aryl hydrocarbon receptor activity and expanding hematopoietic stem cells by culturing hematopoietic stem or progenitor cells in the presence of these agents. Additionally, the disclosure provides methods of treating various pathologies, such as cancer, by administration of these aryl hydrocarbon receptor antagonists. Additionally, the disclosure provides methods of treating various pathologies in a patient by administration of expanded hematopoietic stem cells. The disclosure further provides kits containing aryl hydrocarbon receptor antagonists that can be used for the expansion of hematopoietic stem cells. The disclosure further relates to pharmaceutical compositions comprising the compounds and methods of treating or preventing a disease in which aryl hydrocarbon receptor plays a role.

Inventors:
BOITANO ANTHONY (US)
COOKE MICHAEL (US)
GONCALVES KEVIN (US)
HOBAN MEGAN (US)
Application Number:
US2019/049502
Publication Date:
August 13, 2020
Filing Date:
September 04, 2019
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
MAGENTA THERAPEUTICS INC (US)
International Classes:
C07D213/74; A61K31/519; A61P7/00; A61P35/00; C07D237/20; C07D239/24; C07D239/42; C07D239/48; C07D239/84; C07D249/06; C07D251/46; C07D251/48; C07D253/065; C07D257/04; C07D277/42; C07D277/82; C07D295/205; C07D307/52; C07D307/68; C07D401/04; C07D401/12; C07D403/10; C07D405/04; C07D413/04; C07D413/14; C07D417/12; C07D475/08; C07D487/04; C07D487/12; C07D495/04; C07D513/04
Domestic Patent References:
WO2012102937A22012-08-02
Foreign References:
Other References:
LUCIE STEJSKALOVA ET AL: "Endogenous and Exogenous Ligands of Aryl Hydrocarbon Receptor: Current State of Art", CURRENT DRUG METABOLISM, vol. 12, no. 2, 1 February 2011 (2011-02-01), US, pages 198 - 212, XP055662390, ISSN: 1389-2002, DOI: 10.2174/138920011795016818
GASIEWICZ T A ET AL: "The aryl hydrocarbon receptor has an important role in the regulation of hematopoiesis: Implications for benzene-induced hematopoietic toxicity", CHEMICO-BIOLOGICAL INTERACTIONS, ELSEVIER SCIENCE IRLAND, IR, vol. 184, no. 1-2, 19 March 2010 (2010-03-19), pages 246 - 251, XP026982177, ISSN: 0009-2797, [retrieved on 20091105]
Attorney, Agent or Firm:
ERLACHER, Heidi et al. (US)
Download PDF: