Title:
ARYL HYDROCARBON RECEPTOR MODULATOR
Document Type and Number:
WIPO Patent Application WO/2018/121434
Kind Code:
A1
Abstract:
Disclosed is an aryl hydrocarbon receptor modulator as represented by formula (I) and a pharmaceutically acceptable salt. R' is H, CN, CH2(OH)R0, CmH2m+1, CnH2n-1, CnH2n-3, formula (A), formula (B), or formula (C); two Ra are independently H, or two Ra in combination form =O or =N-W3-R1; A is unsubstituted, or a C6 to C10 aryl ring substituted with 1 to 3 R, a C2 to C10 heteroaryl ring containing 1 to 5 heteroatoms selected from N, O and S, or a 4 to 7-member non-aromatic heterocycle containing 1 to 3 heteroatoms selected from N, O and S and containing a C＝N; Q is R, or unsubstituted, or a C6 to C10 aryl ring substituted with 1 to 3 R, or a C2 to C10 heteroaryl ring containing 1 to 5 heteroatoms selected from N, O and S; and R forms RC by linking with C or forms RN by linking with N. The compound of formula (I) of the present invention can modulate the activities of AhR, thus it can be used for inhibiting the growth of cancer cells and inhibiting tumor cell metastasis and invasion.
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Inventors:
YANG LUQING (CN)
LI GUODONG (CN)
ZHANG SUOMING (CN)
LI GUODONG (CN)
ZHANG SUOMING (CN)
Application Number:
PCT/CN2017/118004
Publication Date:
July 05, 2018
Filing Date:
December 22, 2017
Export Citation:
Assignee:
SHANGHAI ZHENGENE PHARMACEUTICALS CO LTD (CN)
International Classes:
A61K31/4178; C07D417/06; A61K31/4245; A61P35/00; C07D209/12; C07D401/06; C07D403/06; C07D409/06; C07D413/06; C07D417/10; C07D417/14
Domestic Patent References:
| WO2002064138A1 | 2002-08-22 | |||
| WO2016040553A1 | 2016-03-17 |
Foreign References:
| CN102573470A | 2012-07-11 | |||
| US20070043092A1 | 2007-02-22 | |||
| CN102850324A | 2013-01-02 | |||
| CN102573470A | 2012-07-11 |
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BREAST CANCER RES. TREAT., vol. 66, 2001, pages 147
CHERN. REV., vol. 102, 2002, pages 4303
CHEM. REV., vol. 112, 2012, pages 3193
J. BIOL.CHEM., vol. 284, 2009, pages 2690
BIOORG. MED. CHEM., vol. 9, 2001, pages 955
BR. J. CANCER, vol. 88, 2003, pages 599
MAL.CANCER THER., vol. 3, 2004, pages 1565
TOXICOL APPL PHARMACOL., vol. 252, no. 1, 1 April 2011 (2011-04-01), pages 18 - 27
FOOD CHEM., vol. 127, 2011, pages 1764 - 1772
PROC. NATL. ACAD. SCI., vol. 99, 2002, pages 14694 - 9
J. AM. CHEM. SOC., vol. 124, no. 44, 2002, pages 13179 - 13184
J. MED. CHEM., vol. 4, 1961, pages 259 - 296
ONCOGENE, vol. 23, 2004, pages 4400 - 4412
J. BIOMOL. SCREEN, vol. 4, no. 2, 1999, pages 67 - 73
Attorney, Agent or Firm:
WEI YUAN PATENT LAW L.L.C (CN)
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