Title:
ARYL UREIDO DERIVATIVES AND THEIR MEDICAL USE
Document Type and Number:
WIPO Patent Application WO2004046090
Kind Code:
A3
Abstract:
This invention relates to novel aryl ureido benzoic acid derivatives useful as selective and non-competitive antagonists of the ionotropic GluR5 receptor. Due to their biological activity, the aryl ureido derivatives of the invention are considered useful for treating diseases that are responsive to modulation of an aspartate or a glutamate receptor. Moreover the invention provides chemical compounds for use according to the invention, as well as pharmaceutical compositions comprising the chemical compounds, and methods of treating diseases or disorders or conditions responsive to modulation of an aspartate or a glutamate receptor.
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Inventors:
VALGEIRSSON JON (IS)
NIELSEN ELSEBET OESTERGAARD (DK)
PETERS DAN (DK)
NIELSEN ELSEBET OESTERGAARD (DK)
PETERS DAN (DK)
Application Number:
PCT/DK2003/000768
Publication Date:
August 19, 2004
Filing Date:
November 10, 2003
Export Citation:
Assignee:
NEUROSEARCH AS (DK)
VALGEIRSSON JON (IS)
NIELSEN ELSEBET OESTERGAARD (DK)
PETERS DAN (DK)
VALGEIRSSON JON (IS)
NIELSEN ELSEBET OESTERGAARD (DK)
PETERS DAN (DK)
International Classes:
C07C275/42; C07C309/51; C07D209/40; C07D213/75; C07D231/56; C07D257/04; C07D271/07; C07D317/66; C07D333/36; C07D271/06; (IPC1-7): C07C275/42; C07C309/46; C07D209/40; C07D213/72; C07D231/56; C07D257/04; C07D271/07; C07D333/36; A61K31/17; A61K31/19; A61K31/381; A61K31/416; A61K31/4245; A61K31/44
Domestic Patent References:
| WO2000024707A1 | 2000-05-04 | |||
| WO1998047879A1 | 1998-10-29 | |||
| WO1999038846A1 | 1999-08-05 | |||
| WO1999000357A1 | 1999-01-07 | |||
| WO2002039987A2 | 2002-05-23 | |||
| WO1994022807A1 | 1994-10-13 | |||
| WO1997029743A1 | 1997-08-21 | |||
| WO1996025157A1 | 1996-08-22 |
Foreign References:
| US6417393B1 | 2002-07-09 | |||
| US2722544A | 1955-11-01 | |||
| GB709455A | 1954-05-26 | |||
| EP0656350A1 | 1995-06-07 |
Other References:
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; BENNEKOU, POUL ET AL: "Treatment with NS3623, a novel Cl-conductance blocker, ameliorates erythrocyte dehydration in transgenic SAD mice: a possible new therapeutic approach for sickle cell disease", XP002277267, retrieved from STN Database accession no. 2001:169674 CAPLUS
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; BUCKMAN, BRAD O. ET AL: "Solution-phase parallel synthesis of benzoxazines using a polymer-supported carbodiimide", XP002277268, retrieved from STN Database accession no. 1998:159564 CAPLUS
MICHAEL R. PAVIA ET AL: "N-Phenyl-N'-pyridinylureas as anticonvulsant agents1", J. MED. CHEM., vol. 33, 1990, pages 854 - 861, XP002277266, ISSN: 0022-2623
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; BUCKMAN, BRAD O. ET AL: "Solution-phase parallel synthesis of benzoxazines using a polymer-supported carbodiimide", XP002277268, retrieved from STN Database accession no. 1998:159564 CAPLUS
MICHAEL R. PAVIA ET AL: "N-Phenyl-N'-pyridinylureas as anticonvulsant agents1", J. MED. CHEM., vol. 33, 1990, pages 854 - 861, XP002277266, ISSN: 0022-2623
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