Title:
ARYLAMINE-SUBSTITUTED QUINAZOLINONE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO2005005395
Kind Code:
A3
Abstract:
Compounds represented by Formula (I) which are useful as are alpha-1A/B adrenoceptor antagonists, to methods of treating conditions associated with the activity of alpha-1A/B adrenoceptors, and to methods of making said compounds, wherein Ar, Z, R, R', R<5> and R<10> are as defined herein.
Inventors:
CONNOLLY TERRENCE JOSEPH (US)
KEITZ PAUL FRANCIS (US)
LEE EUN KYUNG (US)
LI JIM (US)
LOPEZ-TAPIA FRANCISCO JAVIER (US)
MCGARRY PATRICK FINBAR (US)
MELVILLE CHRIS RICHARD (US)
NITZAN DOV (US)
O'YANG COUNDE (US)
PADILLA FERNANDO (US)
WEINHARDT KLAUS KURT (US)
KEITZ PAUL FRANCIS (US)
LEE EUN KYUNG (US)
LI JIM (US)
LOPEZ-TAPIA FRANCISCO JAVIER (US)
MCGARRY PATRICK FINBAR (US)
MELVILLE CHRIS RICHARD (US)
NITZAN DOV (US)
O'YANG COUNDE (US)
PADILLA FERNANDO (US)
WEINHARDT KLAUS KURT (US)
Application Number:
PCT/EP2004/006973
Publication Date:
May 06, 2005
Filing Date:
June 28, 2004
Export Citation:
Assignee:
HOFFMANN LA ROCHE (CH)
CONNOLLY TERRENCE JOSEPH (US)
KEITZ PAUL FRANCIS (US)
LEE EUN KYUNG (US)
LI JIM (US)
LOPEZ-TAPIA FRANCISCO JAVIER (US)
MCGARRY PATRICK FINBAR (US)
MELVILLE CHRIS RICHARD (US)
NITZAN DOV (US)
O'YANG COUNDE (US)
PADILLA FERNANDO (US)
WEINHARDT KLAUS KURT (US)
CONNOLLY TERRENCE JOSEPH (US)
KEITZ PAUL FRANCIS (US)
LEE EUN KYUNG (US)
LI JIM (US)
LOPEZ-TAPIA FRANCISCO JAVIER (US)
MCGARRY PATRICK FINBAR (US)
MELVILLE CHRIS RICHARD (US)
NITZAN DOV (US)
O'YANG COUNDE (US)
PADILLA FERNANDO (US)
WEINHARDT KLAUS KURT (US)
International Classes:
A61K31/517; A61K31/549; C07D239/90; C07D239/95; C07D285/24; C07D285/26; C07D401/12; C07D401/14; C07D403/12; C07D405/12; C07D413/12; C07D417/02; C07D417/12; (IPC1-7): C07D417/12; A61K31/517; C07D401/12; C07D403/12; C07D413/12
Domestic Patent References:
| WO2002053558A1 | 2002-07-11 | |||
| WO2001010860A2 | 2001-02-15 |
Foreign References:
| DE2258561A1 | 1973-06-20 | |||
| US4442094A | 1984-04-10 | |||
| US6376667B1 | 2002-04-23 |
Other References:
HESS, HANS J. ET AL: "Antihypertensive 2-amino-4(3H)-quinazolinones", JOURNAL OF MEDICINAL CHEMISTRY , 11(1), 130-6 CODEN: JMCMAR; ISSN: 0022-2623, 1968, XP002300297
DERUITER, JACK ET AL: "Design and synthesis of 2-(arylamino)-4(3H)-quinazolinones as novel inhibitors of rat lens aldose reductase", JOURNAL OF MEDICINAL CHEMISTRY , 29(5), 627-9 CODEN: JMCMAR; ISSN: 0022-2623, 1986, XP002300298
M.B.ANDRUS ET AL.: "A Modified Synthesis of Iodoazidoaryl Prazosin", J.ORG.CHEM., vol. 67, 19 October 2002 (2002-10-19), pages 8284 - 8286, XP002315227
DATABASE BEILSTEIN XP002315228, Database accession no. 489679 (REACTION ID)
DERUITER, JACK ET AL: "Design and synthesis of 2-(arylamino)-4(3H)-quinazolinones as novel inhibitors of rat lens aldose reductase", JOURNAL OF MEDICINAL CHEMISTRY , 29(5), 627-9 CODEN: JMCMAR; ISSN: 0022-2623, 1986, XP002300298
M.B.ANDRUS ET AL.: "A Modified Synthesis of Iodoazidoaryl Prazosin", J.ORG.CHEM., vol. 67, 19 October 2002 (2002-10-19), pages 8284 - 8286, XP002315227
DATABASE BEILSTEIN XP002315228, Database accession no. 489679 (REACTION ID)
Download PDF:
Previous Patent: THIOPHENYLAMINOIMIDAZOLINES AS PROSTAGLANDIN I2 ANTAGONISTS
Next Patent: 5-SUBSTITUTED QUINAZOLINONE DERIVATIVES
Next Patent: 5-SUBSTITUTED QUINAZOLINONE DERIVATIVES