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Title:
ARYLGLYCINE DERIVATIVES AND THEIR USE AS GLYCINE TRANSPORT INHIBITORS
Document Type and Number:
WIPO Patent Application WO2004022528
Kind Code:
A3
Abstract:
The present invention relates to compounds of Formula (I), and salts solvates and hydrates thereof. The invention further relates to pharmaceutical compositions containing said compounds and methods of treating neurological, neuropsychiatric, and gastrointestinal disorders using said compounds.

Inventors:
ISAAC METHVIN
XIN TAO
EDWARDS LOUISE
BEGLEITER LEAH
STEFANAC TOMASLAV
O'BRIEN ANNE
DA SILVA KATHLEEN
ARORA JALAJ
MADDAFORD SHAWN
SLASSI ABDELMALIK
Application Number:
CA0301369W
Publication Date:
May 21, 2004
Filing Date:
September 09, 2003
Export Citation:
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Assignee:
NPS ALLELIX CORP.
International Classes:
A61P25/18; A61P25/28; C07C275/40; C07C279/28; C07C335/16; C07C335/18; C07D213/75; C07D215/38; C07D215/40; C07D295/26; C07D333/24; (IPC1-7): C07C335/20; C07C275/40; C07C279/28; C07D295/22; C07D215/40; A61K31/33; A61P25/18; A61P25/28; A61K31/17
Domestic Patent References:
WO2002048099A12002-06-20
WO2003039543A12003-05-15
WO2003093235A12003-11-13
WO2002022581A12002-03-21
Other References:
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOEDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002271212
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOEDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002271213
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOEDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002271214
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOEDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002271215
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOEDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002271216
SANJI HAGISHITA ET AL.: "Synthesis and pharmacological properties of ureidomethylcarbamoylphenylketone derivatives.", BIOORGANIC & MEDICINAL CHEMISTRY., vol. 5, no. 8, 1997, ELSEVIER SCIENCE LTD., GB, pages 1695 - 1714, XP002271211, ISSN: 0968-0896
SARTORI E ET AL: "SYNTHESIS AND ANALGESIC ACTIVITIES OF UREA DERIVATIVES OF ALPHA-AMINO-N-PYRIDYL BENZENE PROPANAMIDE", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 29, no. 6, 1994, pages 431 - 439, XP000917148, ISSN: 0223-5234
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