Title:
ARYLPYRAZOLYLPIPERAZINE OR ARYLPYRAZOLYLDIAZEPANE DERIVATIVE ACTING AS 5-HT7 RECEPTOR REGULATOR AND PHARMACEUTICAL COMPOSITION COMPRISING SAME FOR TREATMENT OR PREVENTION OF CENTRAL NERVOUS SYSTEM DISORDER
Document Type and Number:
WIPO Patent Application WO/2019/107922
Kind Code:
A1
Abstract:
The present invention relates to an arylpyrazolylpiperazine or arylpyrazolyldiazepane derivative represented by Structural Formula 1 and a pharmaceutically acceptable salt thereof. An arylpyrazolylpiperazine or arylpyrazolyldiazepane derivative and a pharmaceutically acceptable salt thereof according to the present invention exhibit excellent affinity for serotonin 5-HT7 receptor and can exert a therapeutic effect on a central nervous system disorder.
Inventors:
CHOO HYUNAH (KR)
KIM YOUNGJAE (KR)
KWAG RINA (KR)
SEONG JIHYE (KR)
LIM SANG MIN (KR)
YEOM MIYOUNG (KR)
LEE JUNG EUN (KR)
LEE HYUNJOO JENNY (KR)
KIM HYUNG GUK (KR)
KIM YOUNGJAE (KR)
KWAG RINA (KR)
SEONG JIHYE (KR)
LIM SANG MIN (KR)
YEOM MIYOUNG (KR)
LEE JUNG EUN (KR)
LEE HYUNJOO JENNY (KR)
KIM HYUNG GUK (KR)
Application Number:
PCT/KR2018/014838
Publication Date:
June 06, 2019
Filing Date:
November 28, 2018
Export Citation:
Assignee:
KOREA INST SCI & TECH (KR)
KOREA ADVANCED INST SCI & TECH (KR)
KOREA ADVANCED INST SCI & TECH (KR)
International Classes:
C07D403/04; A61K31/496; A61P25/00; A61P25/20; A61P25/22; A61P25/24
Domestic Patent References:
| WO2010053388A1 | 2010-05-14 | |||
| WO2009029439A1 | 2009-03-05 |
Foreign References:
| US20080139572A1 | 2008-06-12 |
Other References:
STREKOWSKI, L. ET AL.: "Synthesis and Structure-Activity Relationship Analysis of 5-HT7 Receptor Antagonists: Piperazin-l-yl Substituted Unfused Heterobiaryls", MOLECULES, vol. 21, no. 4, 433, 31 March 2016 (2016-03-31), pages 1 - 22, XP055616141, DOI: 10.3390/molecules21040433
LACIVITA, E. ET AL.: "Structural Modifications of the Serotonin 5-HT7 Receptor Agonist N-(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-21 I) to Improve in Vitro Microsomal Stability: A Case Study", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 120, 14 September 2016 (2016-09-14), pages 363 - 379, XP029618920, DOI: 10.1016/j.ejmech.2016.05.005
LACIVITA, E. ET AL.: "Structural Modifications of the Serotonin 5-HT7 Receptor Agonist N-(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-21 I) to Improve in Vitro Microsomal Stability: A Case Study", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 120, 14 September 2016 (2016-09-14), pages 363 - 379, XP029618920, DOI: 10.1016/j.ejmech.2016.05.005
Attorney, Agent or Firm:
CHUNG HYUN PATENT & LAW FIRM (KR)
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