Title:
ARYLSECOCHOLADIENE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO1998047866
Kind Code:
A3
Abstract:
Compounds of formula (I) as defined by the specification. The compounds are useful in the treatment or prevention of vitamin D dependent disorders, particularly psoriasis, basal cell carcinomas, disorders of keratinization and keratosis, leukemia, osteoporosis, hyperparathyroidism accompanying renal failure, transplant rejection and graft vs. host disease.
Inventors:
BARBIER PIERRE
BAUER FRANZ
MOHR PETER
MULLER MARC
PIRSON WOLFGANG
BAUER FRANZ
MOHR PETER
MULLER MARC
PIRSON WOLFGANG
Application Number:
PCT/EP1998/002116
Publication Date:
February 25, 1999
Filing Date:
April 11, 1998
Export Citation:
Assignee:
HOFFMANN LA ROCHE (CH)
International Classes:
A61K31/59; A61P3/02; A61P17/00; A61P19/10; A61P37/06; C07C35/23; C07C35/32; C07C49/403; C07C49/497; C07C69/88; C07C401/00; C07F7/18; (IPC1-7): C07C401/00
Domestic Patent References:
| WO1995017197A1 | 1995-06-29 | |||
| WO1991009841A1 | 1991-07-11 | |||
| WO1991015475A1 | 1991-10-17 |
Other References:
GRUE-SOERENSEN G ET AL: "Chemistry and biology of 23-oxa-aro- and 23-thia-aro-vitamin D analogs with high antiproliferative and low calcemic activity", PROC. WORKSHOP VITAM. D, vol. 9, 1994, pages 75 - 76, XP002076119
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