ASARUM TOTAL POLYSACCHARIDES EXTRACT HAVING ANTITUSSIVE ACTIVITY AND EXTRACTION METHOD AND USE THEREOF - 1ST AFFILIATED HOSPITAL GUANGZHOU MEDICAL UNIV

Title:

ASARUM TOTAL POLYSACCHARIDES EXTRACT HAVING ANTITUSSIVE ACTIVITY AND EXTRACTION METHOD AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2015/144059

Kind Code:

A1

Abstract:

Disclosed are an asarum total polysaccharides extract having antitussive activity and an extraction method thereof and a use for preparing a medicant for prevention and treatment of coughing. The asarum is extracted with a polar solvent under hot reflux, concentrated under reduced pressure, dried and then dissolved in water, and precipitated by adding ethanol. The precipitate is washed to obtain the asarum total polysaccharides extract. The polysaccharide percent content of the asarum total polysaccharides extract is 60wt%-80wt%. The asarum total polysaccharides extract has the effects of suppressing coughs and prolonging the latent period of coughs, and also has the effects of reducing the sensitivity of coughs and inhibiting airway inflammation, and can be used for preparing a medicament for prevention and treatment of diseases related to coughing.

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Inventors:

LAI KEFANG (CN)
LIU XIAODONG (CN)
ZHONG BONIAN (CN)
ZHONG SHAN (CN)
NIE YICHU (CN)

Application Number:

PCT/CN2015/075054

Publication Date:

October 01, 2015

Filing Date:

March 25, 2015

Export Citation:

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Assignee:

1ST AFFILIATED HOSPITAL GUANGZHOU MEDICAL UNIV (CN)
GUANGZHOU INST RESPIRATORY DISEASE (CN)

International Classes:

A61K36/264; A61K31/715; A61P11/14

Foreign References:

CN104027345A	2014-09-10
CN1459305A	2003-12-03
JPH0680577A	1994-03-22

Other References:

LI, JINGJING ET AL.: "Study on the Separation, Purification and Immunological Activity of Polysaccharides from Asarum Heterotropoides", JOURNAL OF CHANGCHUN TEACHERS COLLEGE ( NATURAL SCIENCE, vol. 27, no. 01, 28 February 2008 (2008-02-28), pages 54 - 58, XP055224813
See also references of EP 3124032A4

Attorney, Agent or Firm:

ADVANCE CHINA IP LAW OFFICE (CN)
广州华进联合专利商标代理有限公司 (CN)

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